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MAP3K1 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAP3K1 → TNF (increases) Nemoto et al., Mol Cell Biol 1998*
  Evidence: MEKK1 is activated by TNF-alpha and in turn potentiate TNF-alpha induced NF-kappaB activation.
• BioCarta nf-kb signaling pathway: TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  

Text-mined interactions from Literome

Baud et al., Genes Dev 1999 : TNF-alpha also enhances the binding of native TRAF2 to MEKK1 and stimulates the kinase activity of the latter
Yujiri et al., Proc Natl Acad Sci U S A 2000 : MEKK1 is not required for TNFalpha or IL-1 regulation of JNK or NF-kappaB activation in macrophages or fibroblasts
Ishizuka et al., Proc Natl Acad Sci U S A 1997 : Aggregation of FcepsilonRI stimulated MEK kinase 1 (MEKK1) activity, which activates JNK kinase (JNKK), the kinase that phosphorylates and activates JNKs. Expression of activated MEKK1 ( DeltaMEKK1 ) in MC/9 cells strongly stimulated JNK activity but only weakly stimulated p38 activity, and it induced a large activation of TNF-alpha promoter regulated luciferase gene expression
Nemoto et al., Mol Cell Biol 1998 : MEKK1 is activated by tumor necrosis factor alpha (TNF-alpha) and interleukin-1 and can potentiate the stimulatory effect of TNF-alpha on IKK and NF-kappaB activation