◀ Back to TNF
MICE — TNF
Text-mined interactions from Literome
Dinges et al., Infect Immun 2001
(Hypersensitivity) :
Mice pretreated with cyclosporine ( Cs ) or neutralizing antibodies against gamma interferon ( IFN-gamma ) did not develop lethal LPS hypersensitivity when injected with TSST-1, and these agents
reduced the enhancement effect of TSST-1 on LPS induced serum
TNF-alpha by 99 and 85 %, respectively
Wright et al., Am J Respir Crit Care Med 2002
(Disease Models, Animal...) :
Mice exposed to smoke showed increases in gene expression of neutrophil chemoattractant macrophage inflammatory protein-2, macrophage chemoattractant protein-1, and TNF-alpha at 2 hours along with increased plasma TNF-alpha ; ZD0892 prevented the increases in macrophage inflammatory protein-2 and macrophage chemoattractant protein-1 expression and
reduced plasma
TNF-alpha levels to baseline
Xu et al., Proc Natl Acad Sci U S A 2008
(Arthritis, Rheumatoid) :
Mice lacking ST2, the IL-33 receptor alpha-chain, developed attenuated collagen induced arthritis ( CIA ) and
reduced ex vivo collagen-specific induction of proinflammatory cytokines ( IL-17,
TNFalpha , and IFNgamma ), and antibody production
Parant et al., Lymphokine Cytokine Res 1991
:
Mice are quite resistant to LPS toxicity but even a small dose
induced a monophasic production of circulating
TNF
Logue et al., Antiviral Res 2010
(Disease Models, Animal...) :
Mice treated with CLDC had significantly
increased serum IFN-gamma,
TNF-alpha , and IL-12, suggesting a strong Th1 biased antiviral activation of the innate immune system
Lai et al., Horm Metab Res 2013
(Fatty Liver) :
Role of
TNF-a in Renal Damage in
Mice Showing Hepatic Steatosis Induced by High Fat Diet