Li et al., Biochem Biophys Res Commun 2007
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These findings provide a new paradigm for biological effects of IGF-1 on MSC and have implications for the development of novel stem cell therapeutic strategies
Granero-Moltó et al., Stem Cells 2011
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Furthermore, using Irs1 ( -/- ) mice as a nonunion fracture model through altered IGF signaling, we demonstrated that the autocrine effect of IGF-I on MSC restored the fracture new bone formation and promoted the occurrence of a well organized callus that bridged the gap