◀ Back to TERT
TERT — WNT2
Text-mined interactions from Literome
Choi et al., PLoS Genet 2008
:
Statistical comparisons to other microarray gene sets using pattern matching algorithms revealed that the
TERT transcriptional response strongly resembles those
mediated by Myc and
Wnt , two proteins intimately associated with stem cell function and cancer
Shkreli et al., Nat Med 2012
(AIDS-Associated Nephropathy...) :
Transgenic
TERT expression in mice
induces marked upregulation of
Wnt signaling and disrupts glomerular structure, resulting in a collapsing glomerulopathy resembling those in human disease, including HIV associated nephropathy ( HIVAN ) ... Human and mouse HIVAN kidneys show increased expression of
TERT and
activation of
Wnt signaling, indicating that these are general features of collapsing glomerulopathies