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CEBPB — SMAD4
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
CEBPB
→
Complex of SMAD3-SMAD4
(decreases, SMAD3/SMAD4 Activity)
Zauberman et al., J Biol Chem 2001*
Evidence: This was abolished by either a constitutively active form of activin A type IB receptor (CAactRIB) or by a combination of Smad3 and Smad4.
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NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
CEBPB (CEBPB)
→
SMAD3/E2F4-5/DP1/p107/SMAD4 complex (SMAD3-E2F5_E2F4-TFDP1-RBL1-SMAD4)
(negative regulation of cell growth, activates)
Chen et al., Cell 2002, Frederick et al., Mol Cell Biol 2004, Gomis et al., Cancer Cell 2006
Evidence: mutant phenotype, reporter gene, physical interaction
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NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-CEBPB)
→
p15INK4b (CDKN2B)
(transcription, activates)
Gomis et al., Cancer Cell 2006
Evidence: mutant phenotype, reporter gene, physical interaction
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NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-CEBPB)
→
CEBPB (CEBPB)
(modification, collaborate)
Gomis et al., Cancer Cell 2006
Evidence: physical interaction
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NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-CEBPB)
→
SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1)
(modification, collaborate)
Gomis et al., Cancer Cell 2006
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
CEBPB (CEBPB)
→
SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1)
(modification, collaborate)
Gomis et al., Cancer Cell 2006
Evidence: physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Bind Interaction:
CEBPB
—
SMAD4
Coyle-Rink et al., Virology 2002*
-
IRef Bind_translation Interaction:
CEBPB
—
SMAD4
(coimmunoprecipitation)
Coyle-Rink et al., Virology 2002*
-
IRef Bind_translation Interaction:
CEBPB
—
SMAD4
(affinity chromatography technology)
Coyle-Rink et al., Virology 2002*
-
IRef Biogrid Interaction:
CEBPB
—
SMAD4
(direct interaction, pull down)
Choy et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
CEBPB
—
SMAD4
(in vivo)
Choy et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
CEBPB
—
SMAD4
(in vitro)
Choy et al., J Biol Chem 2003*
-
IRef Intact Interaction:
CEBPB
—
SMAD4
(direct interaction, pull down)
Coyle-Rink et al., Virology 2002*
-
IRef Intact Interaction:
CEBPB
—
SMAD4
(physical association, anti bait coimmunoprecipitation)
Gomis et al., Cancer Cell 2006
-
IRef Ophid Interaction:
CEBPB
—
SMAD4
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
CEBPB
—
SMAD4
(aggregation, confirmational text mining)
Choy et al., J Biol Chem 2003*
-
IRef Ophid Interaction:
CEBPB
—
SMAD4
(aggregation, confirmational text mining)
Coyle-Rink et al., Virology 2002*
Text-mined interactions from Literome
Zauberman et al., J Biol Chem 2001
:
Electrophoretic mobility shift assays indicated that
C/EBPbeta binding to haptoglobin promoter DNA was
reduced by over-expression of CAactRIB and
Smad4
Nerlov et al., Curr Opin Cell Biol 2008
:
Finally, interaction with Smad proteins, which are accumulated in the nucleus upon TGFbeta or BMP signaling, may lead to the formation of
C/EBP-Smad complexes and
activation of
Smad-C/EBPbeta coregulated promoters, while at the same time inhibiting other C/EBP dependent transcription
Abraham et al., J Interferon Cytokine Res 2009
:
Interestingly, expression of Smad3 and
Smad4 , the downstream regulators of the TGF-beta1 signaling pathway,
impairs the activity of
C/EBPbeta on the TGF-beta1 promoter