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DDB1 — DDB2

Pathways - manually collected, often from reviews:

• Reactome Reaction: DDB1 → DDB2 (reaction) Wood et al., Biochimie 1999, Araújo et al., Mutat Res 1999, Volker et al., Mol Cell 2001
• Reactome Reaction: DDB1 → DDB2 (direct_complex) Wood et al., Biochimie 1999, Araújo et al., Mutat Res 1999, Volker et al., Mol Cell 2001

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: DDB2 — DDB1 Sugasawa et al., Cell 2005*
• IRef Bind Interaction: DDB2 — DDB1 Hayes et al., Mol Cell Biol 1998*
• IRef Bind_translation Interaction: DDB2 — DDB1 (unspecified method) Hayes et al., Mol Cell Biol 1998*
• IRef Bind_translation Interaction: DDB2 — DDB1 (coimmunoprecipitation) Sugasawa et al., Cell 2005*
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Kulaksiz et al., Mol Cell Biol 2005
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Rapić-Otrin et al., Hum Mol Genet 2003*
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Bontron et al., J Biol Chem 2002*
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Olma et al., J Cell Sci 2009
• IRef Biogrid Interaction: DDB2 — DDB1 (association, biochemical) Liu et al., J Biol Chem 2000*
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Bergametti et al., J Virol 2002*
• IRef Biogrid Interaction: DDB2 — DDB1 (direct interaction, pull down) Martinez et al., Mol Cell Biol 2001
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Guerrero-Santoro et al., Cancer Res 2008*
• IRef Biogrid Interaction: DDB2 — DDB1 (direct interaction, pull down) Jin et al., Mol Cell 2006
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Angers et al., Nature 2006
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Higa et al., Nat Cell Biol 2006
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Kapetanaki et al., Proc Natl Acad Sci U S A 2006*
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Wang et al., Mol Cell 2006*
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Takedachi et al., Mol Cell Biol 2010*
• IRef Biogrid Interaction: DDB2 — DDB1 (association, x-ray crystallography) Fischer et al., Cell 2011*
• IRef Biogrid Interaction: DDB2 — DDB1 (association, x-ray crystallography) Scrima et al., Cell 2008*
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Groisman et al., Cell 2003
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Schröfelbauer et al., Proc Natl Acad Sci U S A 2007*
• IRef Biogrid Interaction: DDB2 — DDB1 (physical association, affinity chromatography technology) Inoki et al., Biochem Biophys Res Commun 2004*
• MIPS CORUM Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1): Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) complex (CUL4A-CUL4B-DDB1-DDB2-RBX1) Wang et al., Mol Cell 2006*
• MIPS CORUM DDB2 complex: DDB2 complex complex (COPS2-COPS3-COPS4-COPS5-COPS6-COPS8-CUL4A-DDB1-DDB2-GPS1-RBX1-COPS7A-COPS7B) Groisman et al., Cell 2003
• MIPS CORUM DDB complex: DDB complex complex (DDB1-DDB2) Wittschieben et al., J Biol Chem 2005*
• IRef Corum Interaction: DDB2 — DDB1 (association, affinity chromatography technology) Wittschieben et al., J Biol Chem 2005*
• IRef Corum Interaction: DDB2 — DDB1 (association, cosedimentation in solution) Wittschieben et al., J Biol Chem 2005*
• IRef Corum Interaction: Complex of 11 proteins (association, ion exchange chromatography) Wang et al., Mol Cell 2006*
• IRef Corum Interaction: Complex of 27 proteins (association, cosedimentation through density gradient) Groisman et al., Cell 2003
• IRef Dip Interaction: Complex of XPC-DDB2-DDB1 (anti tag coimmunoprecipitation) Fei et al., PLoS Biol 2011*
• IRef Dip Interaction: DDB2 — DDB1 (direct interaction, atomic force microscopy) Yeh et al., Proc Natl Acad Sci U S A 2012*
• IRef Dip Interaction: DDB2 — DDB1 (direct interaction, x-ray crystallography) Yeh et al., Proc Natl Acad Sci U S A 2012*
• IRef Dip Interaction: DDB2 — DDB1 (direct interaction, dynamic light scattering) Yeh et al., Proc Natl Acad Sci U S A 2012*
• IRef Dip Interaction: DDB2 — DDB1 (direct interaction, anti tag coimmunoprecipitation) Fei et al., PLoS Biol 2011*
• IRef Dip Interaction: DDB2 — DDB1 (direct interaction, anti tag coimmunoprecipitation) Yeh et al., Proc Natl Acad Sci U S A 2012*
• IRef Dip Interaction: DDB2 — DDB1 (direct interaction, x-ray crystallography) Li et al., Nature structural & molecular biology 2010*
• IRef Dip Interaction: DDB2 — DDB1 (direct interaction, transmission electron microscopy) Yeh et al., Proc Natl Acad Sci U S A 2012*
• IRef Dip Interaction: DDB2 — DDB1 (direct interaction, pull down) Yeh et al., Proc Natl Acad Sci U S A 2012*
• IRef Hprd Interaction: DDB2 — DDB1 (in vitro) Bergametti et al., J Virol 2002*, Angers et al., Nature 2006, Ohtake et al., Nature 2007
• IRef Hprd Interaction: DDB2 — DDB1 (in vivo) Bergametti et al., J Virol 2002*, Angers et al., Nature 2006, Ohtake et al., Nature 2007
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Martinez et al., Mol Cell Biol 2001
• IRef Intact Interaction: Complex of 22 proteins (association, tandem affinity purification) Fang et al., J Proteome Res 2008
• IRef Intact Interaction: Complex of 32 proteins (physical association, tandem affinity purification) Hutchins et al., Science 2010
• IRef Intact Interaction: DDB2 — DDB1 (direct interaction, x-ray crystallography) Scrima et al., Cell 2008*
• IRef Intact Interaction: DDB2 — DDB1 (physical association, anti bait coimmunoprecipitation) Higa et al., Nat Cell Biol 2006
• IRef Intact Interaction: DDB2 — DDB1 (direct interaction, anti tag coimmunoprecipitation) Hayes et al., Mol Cell Biol 1998*
• IRef Intact Interaction: Complex of DDB2-CUL4B-DDB1 (association, anti bait coimmunoprecipitation) Higa et al., Nat Cell Biol 2006
• IRef Intact Interaction: Complex of 43 proteins (physical association, anti tag coimmunoprecipitation) Behrends et al., Nature 2010
• IRef Mppi Interaction: DDB2 — DDB1 (coimmunoprecipitation) Hayes et al., Mol Cell Biol 1998*

Text-mined interactions from Literome

Kim et al., Liver 2000 : Effects of DDB on the expression of xenobiotic metabolizing enzymes and on nuclear factor-kappaB (NF-kappaB) activation and tumor necrosis factor-alpha (TNF-alpha) production by lipopolysaccharide (LPS), an endotoxin involved in inflammatory responses, were examined in rats and in RAW264.7 cells to investigate mechanistic aspects ... Effects of DDB on the expression of xenobiotic metabolizing enzymes and on nuclear factor-kappaB (NF-kappaB) activation and tumor necrosis factor-alpha (TNF-alpha) production by lipopolysaccharide (LPS) , an endotoxin involved in inflammatory responses, were examined in rats and in RAW264.7 cells to investigate mechanistic aspects ... Effects of DDB on the expression of xenobiotic metabolizing enzymes and on nuclear factor-kappaB (NF-kappaB) activation and tumor necrosis factor-alpha (TNF-alpha) production by lipopolysaccharide (LPS), an endotoxin involved in inflammatory responses, were examined in rats and in RAW264.7 cells to investigate mechanistic aspects ... LPS induced I-kappaBalpha degradation and TNF-alpha production were also inhibited by DDB in RAW264.7 cells, which was consistent with the results in rats ... LPS induced I-kappaBalpha degradation and TNF-alpha production were also inhibited by DDB in RAW264.7 cells, which was consistent with the results in rats
Cong et al., J Biol Chem 2002 : Significantly, overexpression of c-Abl increased tyrosine phosphorylation of DDB2 and suppressed UV-DDB activity ... These results suggest that one role of c-Abl may be to negatively regulate UV-DDB activity by phosphorylation of DDB2
Hartman et al., Nat Genet 2002 (Breast Neoplasms) : Here we show that BRCA1 specifically enhances the GGR pathway, independent of p53, and can induce p53 independent expression of the NER genes XPC, DDB2 , and GADD45
Lu et al., Yao Xue Xue Bao 2002 (Disease Models, Animal...) : DDB significantly increased the liver cytochrome P450 content, P450 isozyme 2B1 mediated 7-pentoxyresorufin O-dealkylase ( PROD ) activity, cytosolic glutahione ( GSH ) level and GSH S-transferase (GST) activities
Leupin et al., J Virol 2003 : Thus, SV5-V and HBx bind to DDB1 in a mutually exclusive manner, and SV5-V shares with HBx the ability to enhance the steady-state levels of DDB1 and to inhibit its association with DDB2
Itoh et al., Mol Cell Biol 2003 (Xeroderma Pigmentosum) : We propose that both before and after UV irradiation, DDB2 directly regulates p53 levels, while DDB2 expression is itself regulated by p53
el-Sawy et al., East Mediterr Health J 2002 (Disease Models, Animal...) : DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically injured liver ... DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically injured liver ... DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase , and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically injured liver
Gao et al., Liver Int 2005 (Disease Models, Animal...) : These results suggest that DDB could directly protect hepatocyte DNA from oxidative damage, and inhibit TNF-alpha mRNA expression in liver tissue, which resulted in prevention of liver damage induced by Con A in mice
Chen et al., Mol Cell 2006 : Biochemical studies revealed that c-Abl promotes CUL-4A mediated DDB ubiquitination and degradation in a manner that does not require its tyrosine kinase activity both under normal growth conditions and following UV irradiation ... Moreover, c-Abl activates DDB degradation in part by alleviating the inhibitory effect of CAND1/TIP120A on CUL-4A
Jin et al., Invest New Drugs 2007 (Anemia...) : DDB increased the intracellular accumulation of doxorubicin and inhibited surface P-gp expression in MCF-7/Adr cells
Abdel-Salam et al., TheScientificWorldJournal 2007 (Liver Cirrhosis, Experimental) : Silymarin treatment resulted in 34.6 and 30 % decrease in ALT and AST, while DDB ( 75 mg/kg ) combined with silymarin ( 22 mg/kg ) resulted in 58.2 and 31 % decrease in ALT and AST , respectively
Stoyanova et al., Mol Cell Biol 2008 (Xeroderma Pigmentosum) : We show that DDB2 enhances nuclear accumulation of DDB1 , which binds to a modified form of p53 containing phosphorylation at Ser18 ( p53 ( S18P ) ) and targets it for degradation in low-dose-UV irradiated cells
Hu et al., Genes Dev 2008 : Conversely, depletion of FBW5, DDB1 , or CUL4A/B stabilizes TSC2
Xie et al., J Ethnopharmacol 2010 (Disease Models, Animal...) : Integral pharmacokinetics of multiple lignans based on an AUC weighting approach was determined in normal, CCl4 induced hepatic injury rats pretreated with or without SLE and DDB ... Integral pharmacokinetics of multiple lignans based on an AUC weighting approach was determined in normal, CCl4 induced hepatic injury rats pretreated with or without SLE and DDB
Lee et al., Int J Clin Pharmacol Ther 2012 (Disease Progression...) : The effects of DDB plus GO on decreases in ALT and AST levels lasted until 1 week after completion of treatment
Liu et al., Cancer Lett 1995 : DDB induced rat hepatic cytochrome P450IA1, IIB1 and glutathione S-transferase activities ... It is concluded that the protective effect of DDB against AFB1 induced damage might be mediated by the induced glutathione S-transferase activity and not from the accelerated hepatic cytochrome P450 detoxification pathway of AFB1 which was previously believed
Liu et al., Zhonghua Yi Xue Za Zhi 1995 (Carcinoma, Hepatocellular...) : DDB at the concentration of 10 ( -4 ) M could significantly increase the content of cAMP in Bel-7402 cells, and also suppressed the expressions of oncogene c-myc and hepatocarcinoma marker AFP gene and enhanced the anti-oncogene p53 expression
Liu et al., Cancer Lett 1996 (Carcinoma, Hepatocellular...) : DDB ( 10 ( -4 ) M ) could significantly increase the content of cAMP in Bel-7402 cells, and also enhance the expression of anti-oncogene p53