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NGF — SPHK1

Text-mined interactions from Literome

Edsall et al., J Neurochem 2001 (Adrenal Gland Neoplasms...) : NGF , which protects PC12 cells from serum withdrawal induced apoptosis, also stimulated SPHK1 activity
Sobue et al., J Neurochem 2005 (Pheochromocytoma) : Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12 ... NGF induced an increase in SPHK enzyme activity and protein about double those in PC12 cells, and NGF induced SPHK1 mRNA was three times higher than in the control ... The minimal 5 ' promoter was determined, and TrkA specific inhibitor K252a inhibited the NGF induced promoter activity of SPHK1 ... These results suggest the signal transduction pathway from NGF receptor TrkA to transcription factor Sp1 protein binding to the promoter Sp1-like motif in NGF induced rat SPHK1 gene expression
Edsall et al., J Neurosci 1997 : Nerve growth factor (NGF) , a neurotrophic factor for pheochromocytoma PC12 cells, induced a biphasic increase in the activity of sphingosine kinase , the enzyme that catalyzes the formation of SPP
Rius et al., FEBS Lett 1997 (Pheochromocytoma) : Nerve growth factor (NGF) , basic fibroblast growth factor (bFGF), dibutyryl cAMP and forskolin, known differentiating agents for pheochromocytoma PC12 cells, induced sustained activation of sphingosine kinase , the enzyme responsible for the formation of the sphingolipid second messenger, sphingosine-1-phosphate, which mediates the mitogenic effects of certain growth factors ... Of the growth factors examined, NGF was the most potent activator of sphingosine kinase , inducing a 4-fold increase in Vmax