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HIF1A — HIF3A

Pathways - manually collected, often from reviews:

• NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha: ARNT/IPAS complex (ARNT-HIF3A) → HIF1A (HIF1A) (modification, collaborate) Isaacs et al., J Biol Chem 2004*, Jang et al., Biochem Biophys Res Commun 2005*, Wang et al., Proc Natl Acad Sci U S A 1995*, Jiang et al., J Biol Chem 1996*, Gradin et al., Mol Cell Biol 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha: ARNT/IPAS complex (ARNT-HIF3A) → HIF1A/ARNT complex (HIF1A-ARNT) (modification, collaborate)
  Isaacs et al., J Biol Chem 2004*, Jang et al., Biochem Biophys Res Commun 2005*, Wang et al., Proc Natl Acad Sci U S A 1995*, Jiang et al., J Biol Chem 1996*, Gradin et al., Mol Cell Biol 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha: HIF1A (HIF1A) → IPAS (HIF3A) (modification, collaborate) Isaacs et al., J Biol Chem 2004*, Jang et al., Biochem Biophys Res Commun 2005*, Wang et al., Proc Natl Acad Sci U S A 1995*, Jiang et al., J Biol Chem 1996*, Gradin et al., Mol Cell Biol 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha: IPAS (HIF3A) → HIF1A/ARNT complex (HIF1A-ARNT) (modification, collaborate)
  Isaacs et al., J Biol Chem 2004*, Jang et al., Biochem Biophys Res Commun 2005*, Wang et al., Proc Natl Acad Sci U S A 1995*, Jiang et al., J Biol Chem 1996*, Gradin et al., Mol Cell Biol 1996
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: HIF1A → HIF3A (reaction) Iwai et al., Proc Natl Acad Sci U S A 1999, Ohh et al., Nat Cell Biol 2000, Kamura et al., Proc Natl Acad Sci U S A 2000, Berra et al., EMBO Rep 2001, Groulx et al., Mol Cell Biol 2002, Maynard et al., J Biol Chem 2003, Lee et al., Mol Cell Biol 1999

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: HIF1A — HIF3A (in vivo) Makino et al., Nature 2001*
• IRef Innatedb Interaction: HIF1A — HIF3A (unknown, -) Maynard et al., FASEB J 2005*

Text-mined interactions from Literome

Bonnet et al., Circulation 2006 (Anoxia...) : Like FHRs, human PAH-PASMCs had dysmorphic, hyperpolarized mitochondria ; normoxic HIF-1alpha activation ; and reduced expression/activity of HIF-3alpha , cytochrome c oxidase, and superoxide dismutase-2
Chen et al., Acta Biochim Biophys Sin (Shanghai) 2006 (Anoxia) : HIF-1alpha and HIF-2alpha mRNA increased slightly after 7 d of hypoxia, but HIF-3alpha increased significantly after 3 d of hypoxia
Forristal et al., Reproduction 2010 : HIF3A upregulated HIF2A and prevented HIF1A expression with the knockdown of HIF3A resulting in the reappearance of HIF1A protein