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CD40 — TLR5
Text-mined interactions from Literome
Funderburg et al., Proc Natl Acad Sci U S A 2007
:
Here, we show that human beta-defensin-3 (hBD-3), an innate antimicrobial peptide, can induce expression of the costimulatory molecules CD80, CD86, and
CD40 , on monocytes and myeloid dendritic cells in a
TLR dependent manner
Movita et al., J Leukoc Biol 2012
:
Interestingly, despite expression of TLR mRNA on Kupffer cells, ligation of TLR4,
TLR7/8 , and TLR9
resulted in a weak induction of IL-10, low or undetectable levels of IL-12p40 and TNF, and up-regulation of
CD40 on the surface
Ori et al., J Immunol 2013
:
TAB2 and TAB3 are critical for the activation of MAPKs, especially ERK, but not NF-?B, in
response to
TLR and
CD40 stimulation in B cells