Qureshi et al., J Cell Physiol 2005
:
Depletion of Sp1 by transfection of an antisense phosphorothioate oligonucleotide suppressed TGF-beta induced TIMP-3 protein expression, while its sense homolog had no effect ... These results suggest that activation of ERK-MAPK pathway and Sp1 transcription factor play a pivotal role in the induction of TIMP-3 by TGF-beta in chondrocytes
Qureshi et al., Cell Signal 2007
:
PI3K p85, Akt and Sp1 small interfering RNA ( siRNA ) -driven knockdown of the respective gene products significantly suppressed TGF-beta induced TIMP-3 gene expression
Chetty et al., Cancer Res 2008
(Lung Neoplasms...) :
In addition, electrophoretic mobility shift and chromatin immunoprecipitation assays show that Sp1 transcription factor mediated Ad-MMP-2-Si-CM stimulated increase of TIMP-3