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HSPD1 — TNF

Text-mined interactions from Literome

Bajramović et al., J Neuroimmunol 2000 : Hsp60 expression was found to be enhanced in response to cytokines as diverse as IL-1beta, TNF-alpha , IL-4, IL-6 and IL-10
Ueki et al., Clin Exp Immunol 2002 (Chronic Disease...) : In order to clarify the relative importance of hsp60 in the inflammatory response in periodontal disease, the stimulatory effect of human and bacterial hsp60 on the production of tumour necrosis factor-alpha (TNF-alpha) was examined in phorbol myristate acetate ( PMA ) -stimulated THP-1 cells
Gao et al., J Biol Chem 2003 : Recent studies have shown that commercially available recombinant human heat shock protein 60 ( rhHSP60 ) could induce tumor necrosis factor alpha (TNF-alpha) release from macrophages and monocytes in a manner similar to that of lipopolysaccharide (LPS), e.g. via CD14 and Toll-like receptor 4 complex mediated signal transduction pathway
Zhang et al., Infect Immun 2004 : Moreover, hsp60 increased the level of tumor necrosis factor alpha (TNF-alpha) in culture medium in a dose dependent manner
Iwahashi et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : Hsp60 could stimulate TNFalpha production by adhered monocytes, which was inhibited similarly by anti-TLR-2 antibody and anti-TLR-4 antibody
Schuchmann et al., Immunol Lett 2004 (Liver Failure) : In cultivated KC, autologous HSP60 induced a state of LPS-hyporesponsiveness ; bacterial DNA did not mitigate the response to subsequent LPS-challenge in vitro ; in contrast, pre-treatment of mice with bacterial DNA even significantly increased serum TNF levels, liver function tests and mortality in a model of LPS induced hemorrhagic liver failure
Osterloh et al., J Biol Chem 2004 : The induction of tumor necrosis factor-alpha secretion in mouse macrophages is lost after endotoxin removal and is not mediated by Hsp60 expressed in eukaryotic systems
Yokota et al., Int Immunol 2006 (Autoimmune Diseases) : We found that a murine anti-HSP60 mAb enhanced the production of IL-8 and tumor necrosis factor-alpha induced by human HSP60 in the human monocytic cell lines THP-1 and U937, and human peripheral blood monocytes
Bangen et al., Biochem Biophys Res Commun 2007 (Inflammation) : Neither HSP60 nor HSP70 alone induced the release of TNF-alpha
Osterloh et al., Int Immunol 2008 : LPS-free Hsp60 did not induce IL-6, IL-12 or tumor necrosis factor alpha production in APC nor were these cytokines needed for Hsp60 mediated T cell co-stimulation in the absence of LPS
Wang et al., J Mol Cell Cardiol 2010 (Heart Failure) : TNFalpha increased HSP60 expression, and this could be prevented by pretreatment with siRNA inhibiting p65 expression
Kobba et al., Shock 2011 : TNF/HS resulted in an increase in HS protein (HSP) 60 , compared with untreated cells, those receiving HS/TNF, or TNF alone
Kamalakannan et al., Microbes Infect 2012 (Filariasis...) : Recombinant Wolbachia heat shock protein 60 ( rWmhsp60 ) induces gene expression of pro-inflammatory cytokines IL-1ß, IL-6 and TNF-a in human monocytic cell line THP-1
Teng et al., Mol Med Report 2013 : Furthermore, the enhanced expression of HSP60 was reduced and the LPS induced release of TNF-a and HSP60 were inhibited
Kol et al., Circulation 1998 (Arteriosclerosis...) : Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression ... Both C pneumoniae and recombinant chlamydial HSP 60 induced TNF-alpha production by mouse macrophages in a concentration- and time dependent fashion ... Chlamydial and human HSP 60 induce TNF-alpha and MMP production by macrophages