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BMP2 — DLX5
Text-mined interactions from Literome
Holleville et al., Dev Biol 2003
:
BMP signals
regulate Dlx5 during early avian skull development
Lee et al., Biochem Biophys Res Commun 2003
:
BMP-2 stimulates the expression of three osteogenic master transcription factors : Runx2,
Dlx5 , and Osterix ( Osx )
Takagi et al., J Mol Histol 2004
:
BMP-2 also
stimulated significantly
Dlx5 expression on days 3-9, Msx2 and matrix Gla protein expressions on days 3 and 6, Runx2, alkaline phosphatase and osteocalcin expressions on days 6 and 9 in the culture
Kim et al., J Biol Chem 2004
:
Its expression is stimulated by bone morphogenetic protein (BMP)-2 treatment, the
activation of
BMP receptors and R-Smads, and the expression of
Dlx5 and Runx2
Singhatanadgit et al., J Cell Physiol 2006
:
Pre-incubation of the cells with the growth factors significantly augmented
BMP-2 induced Smad1/5/8 phosphorylation, and
Dlx5 expression ALP activity, compared with that of cells treated with BMP-2 alone
Lee et al., Mol Cells 2006
:
In addition,
BMP-2 stimulation
induced Dlx5 expression by hypomethylating its promoter
Holleville et al., Dev Biol 2007
:
Thirdly, we show that
BMP signaling
activates Dlx5 , Runx2, and alkaline phosphatase in those primary cultures and that a dominant negative Dlx factor interferes with the ability of the BMP pathway to activate Runx2 expression
Ulsamer et al., J Biol Chem 2008
:
BMP-2 induces Osterix expression through up-regulation of
Dlx5 and its phosphorylation by p38 ... First,
BMP-2 induction of
Dlx5 precedes the induction of Osterix
Kato et al., Life Sci 2009
:
BMP-2 increased not only mRNA and protein expressions of
Dlx5 followed by inducing Osterix and BSP levels in a dose- and time dependent manner with an increase in Runx2, Msx2, AJ18, ALP and OC levels, but also induced PPARgamma2 and aP2 levels
Takahashi et al., Arch Oral Biol 2013
:
In addition,
BMP6 enhances gene expression levels of
DLX-5 , Runx2, and Osterix, which are transcription factors associated with osteogenic differentiation