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IL2 — PRKAR1A
Text-mined interactions from Literome
Poluektova et al., Immunopharmacology 1999
:
In this report we explore the
role of
PKA in histamine mediated effects on
IL-2 mRNA expression and IL-2 protein secretion
Bryce et al., Immunopharmacology 1999
:
It has been demonstrated that the inhibitory effects of pharmacological elevations in cAMP on human T cell proliferation and
IL-2 production do not
require PKA activity
Herring et al., Cell Signal 2001
(MAP Kinase Signaling System) :
Therefore, the objective of the present studies was to determine the
role of cAMP and
protein kinase A (PKA) in the CBN mediated inhibition of
IL-2 , CREB, and NF-kappaB in PMA/Io activated thymocytes
Williams et al., J Immunol 2002
:
Disruption of the
AKAP-PKA interaction
caused high levels of
IL-2 , IL-4, IL-5, and IFN-gamma production in the absence of stimulation via CD3epsilon and CD28 molecules
Hughes-Fulford et al., Cell Signal 2005
:
Gene expression of
IL-2R ( alpha ) and IFN(gamma) was
dependent on
PKA in S49 wt cells but not in kin- mutants ... Taken together, these results suggest that the
PKA in addition to PKC and MAPK pathways
plays a role in early T-cell activation and induction of IL-2,
IL-2R ( alpha ) and IFN(gamma) gene expression
Rodriguez et al., J Biol Chem 2013
:
Taken together, these findings suggest that Fsk activation of adenylate cyclase and
PKA can negatively
regulate IL-2 signaling at multiple levels that include IL-2R complex formation and Jak3/Stat5 activation
Neumann et al., EMBO J 1995
:
In CD4+ T helper cells, stimulation of
PKA leads to suppression of
interleukin 2 (IL-2) induction, while induction of the genes coding for the lymphokines IL-4 and IL-5 is enhanced ... We show that the differential
effect of
PKA activity on induction of the
IL-2 and IL-4 genes is mediated through their promoters ... Mutations preventing factor binding to the IL-2 kappa B site result in a loss of
PKA mediated suppression of
IL-2 promoter activity
Sugiyama et al., J Immunol 1997
:
The
role of cAMP dependent
protein kinase (PKA) in the regulation of TCR triggered
IL-2 secretion was studied by transfecting T hybridoma cells with cDNA encoding the inhibitory regulatory subunit ( RI alpha ) of PKA with mutations in cAMP binding sites ( RI alpha ( m ) ) or by pretreating T cells with catalytic subunit-alpha ( C alpha ) antisense mRNA oligonucleotides