Noh et al., Mol Biol (Mosk) 2012
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We examined whether N-acetylcysteine (NAC) enhanced embryonic body ( EB ) formation and neuronal differentiation in terms of EB formation, neuronal marker ( microtubule associated protein 2 ; MAP-2 ) expression, and neuron maturation using P19 embryonic stem cells
Kamata et al., J Biol Chem 1996
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N-acetyl-L-cysteine (NAC) , which acts as a reductant in cells both by its direct reducing activity and by increasing the synthesis of the cellular antioxidant glutathione, inhibited neuronal differentiation induced by NGF or by the expression of oncogenic ras in PC12 cells ... Thus, NAC suppresses NGF induced neuronal differentiation by uncoupling the signal transduction from Ras to the MAP kinase cascade in PC12 cells