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CHUK — CSF2
Text-mined interactions from Literome
Ebner et al., Blood 2003
:
Functional studies demonstrated
GMCSF dependent activation of
IkappaB kinase activity in endothelial cells, degradation of IkappaB, and activation of NF-kappaB
Catley et al., Br J Pharmacol 2005
(Asthma) :
Similarly,
IKK beta ( KA ) and I kappa B alpha delta N overexpression also
inhibited IL-1beta- and TNF alpha dependent increases in ICAM-1, IL-8 and
GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression, whereas IKK alpha ( KM ) overexpression had little effect on these outputs
Brummer et al., Med Mycol 2005
(Inflammation) :
We postulated that DEX inhibition of NF-kappaB was opposed by
induction of
IkappaB kinases (IKK) by
GM-CSF + conidia stimulation, degradation of IkappaB, and release of nuclear factor kappa B (NF-kappaB)
Catley et al., Mol Pharmacol 2006
(Pulmonary Disease, Chronic Obstructive) :
As observed above, ICAM-1, IL-6, IL-8,
GM-CSF , RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was
reduced by the
IKK inhibitors
Grund et al., Mol Pharmacol 2008
(Endometriosis...) :
Interestingly, MEK, p38, and
IKK inhibitors
block TNF-alpha induced IL-8, IL-6, and
GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not