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AKT2 — SLC22A3
Text-mined interactions from Literome
Cho et al., Biochem Biophys Res Commun 2007
:
In this report, we suggest phosphatidylinositol 3-OH kinase
(PI3K)/Akt signaling is also
necessary for TGF-beta induced
EMT in lens epithelial cells by showing that LY294002, an inhibitor of the p110 catalytic subunit of PI3K, blocked the expression of alpha-smooth muscle actin ( alpha-SMA ) and morphological changes
Ho et al., Mol Cancer Res 2012
(Carcinoma, Renal Cell...) :
Inhibition of
PI3K/AKT by LY294002 reactivated GSK-3ß and
suppressed the TNF-a induced
EMT of RCC cells
Han et al., PloS one 2012
(Breast Neoplasms...) :
The inhibitors of
PI3K-AKT and ERK1/2 pathways, LY294002 and U0126, both significantly
suppressed EMT and CSC phenotype, indicating that AKT and ERK1/2 pathways are required for miR-21 mediating EMT and CSC phenotype