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BCL2 — PI3

Text-mined interactions from Literome

Fornoni et al., Am J Pathol 2001 : The regulation of Bcl-xL by HGF was mediated by the PI3'-K but not by the MEK-1 pathway
van der Kuip et al., Blood 2001 : The fibronectin mediated antiapoptotic mechanism in Bcr-Abl-active cells was not mediated by overexpression of Bcl-XL or Bcl-2 but required an active phosphatidylinositol 3-kinase (PI-3K)
Ducrey-Rundquist et al., J Virol 2002 : Furthermore, the phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin blocked IL-7 induced cell survival and Bcl-2 synthesis but had no effect on the acquisition of HIV susceptibility, suggesting that IL-7 induced HIV type 1 permissiveness is not mediated by the PI-3 K pathway and that, perhaps, the Jak/STAT5 pathway, the other known mediator of IL-7 triggered signaling in T cells, governs this process
Karlsson et al., J Leukoc Biol 2003 : The addition of LY294002 did not affect the expression of Bcl-2 and Bcl-XL, and thus, we conclude that expression of antiapoptotic Bcl-2 family member genes is not dependent on PI-3 kinase activity
Bae et al., Cancer Res 2006 (Adenocarcinoma...) : Bcl-w overexpression also activated phosphoinositide 3-kinase (PI3K) , Akt, and Sp1, and the blocking effects of each of these components using pharmacologic inhibitors, dominant negative mutants, or small interfering RNA abolished the ability of Bcl-w to induce MMP-2 and cell invasion
Liang et al., Nat Cell Biol 2006 (Carcinoma...) : The autophagic activity of the Beclin1-PI(3)KC3 complex, however, is suppressed by Bcl-2
Creson et al., J Mol Neurosci 2009 (MAP Kinase Signaling System...) : Evidence for involvement of ERK, PI3K , and RSK in induction of Bcl-2 by valproate
Moriya et al., Hepatology 2012 (Disease Models, Animal...) : This retained expression of Bcl-xL is inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002