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CD40LG — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CD40LG → TNF (increases)
  Evidence: proinflammatory cytokines, such as IL-1, IL-12, TNF-, or IFN-, as well as glucocorticoids, induce expression of the ligand in T lymphocytes,
• OpenBEL Selventa BEL large corpus: CD40LG → TNF (increases)
  Evidence: Interestingly, although these cytokines also induced the expression of CD40L, the ligand for the membrane receptor CD40, treatment with NAC or DPI did not affect increased CD40L expression in these cells (results not shown).
• OpenBEL Selventa BEL large corpus: TNF → CD40LG (increases)
  Evidence: CD40L induces expression of tumor necrosis factor-a, interferon-g, IL-1, IL-6, and IL-8 in peripheral blood monocytes [71,72]

Text-mined interactions from Literome

von Leoprechting et al., Cancer Res 1999 (Melanoma) : CD40 ligation on MM by CD40L transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6, IL-8, tumor necrosis factor-a , and granulocyte macrophage colony stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB
Tripp et al., J Immunol 2000 : These studies show that coincident expression of CD40L enhances the Th1 ( IL-2 and IFN-gamma ) cytokine responses, increases the expression of TNF-alpha and NO, accelerates virus clearance, and increases the anti-F and anti-G Ab responses
Woltman et al., Eur J Immunol 2000 : Furthermore, Dex-DC showed a decreased CD40 ligand induced IL-6 and TNF-alpha production, a complete block in IL-12p40 production, while IL-10 production was unaffected
Bolacchi et al., Cytokine 2001 : The priming effect of CD40L on TNF-alpha and IL-1 beta production was related to induction of CD40 expression
Suo et al., J Neurochem 2002 : Furthermore, although not directly inducing tumor necrosis factor-alpha (TNF-alpha) release, PAR1 activation up-regulates microglial CD40 expression and potentiates CD40 ligand induced TNF-alpha production, thus indirectly contributing to microglial activation
Doucet et al., Eur J Immunol 2002 (Inflammation) : Human lung myofibroblasts as effectors of the inflammatory process : the common receptor gamma chain is induced by Th2 cytokines, and CD40 ligand is induced by lipopolysaccharide, thrombin and TNF-alpha
Asgeirsdóttir et al., Biochem Pharmacol 2003 : Relative and competitive RT-PCR analysis verified downregulation of TNFalpha mediated expression of CD40L and IL-8 by Dexa and Dexa-Ab ( hEsel ), respectively
Andrade et al., J Immunol 2003 : TNF-alpha mediated the effects of CD154 on macrophage anti-T ... CD154 increased TNF-alpha production by T. gondii infected macrophages, and neutralization of TNF-alpha inhibited the effect of CD154 on macrophage anti-T
Smed-Sörensen et al., Blood 2004 (HIV Infections) : CD40L stimulation induced significant secretion of tumor necrosis factor alpha (TNFalpha) and interleukin 12 (IL-12) p70 from both HIV-1 exposed and unexposed DCs
Burger et al., J Immunol 2004 : Differential induction of IL-1beta and TNF by CD40 ligand or cellular contact with stimulated T cells depends on the maturation stage of human monocytes
French et al., Blood 2005 (Sezary Syndrome) : Importantly however, the inability of SzS PBMCs to appropriately produce IL-12 and TNF-alpha could be restored by recombinant hexameric CD40L
Zamorano-León et al., J Cardiovasc Pharmacol 2006 : TNF-alpha stimulated the expression of both CD40L and PECAM in cultured BAEC
Sui et al., J Immunol 2007 (AIDS Dementia Complex...) : Finally, the CD40L mediated increase in TNF-alpha production by monocytes was shown to be biologically important ; immunodepletion experiments revealed that TNF-alpha was essential for the neurotoxic effects of conditioned medium recovered from Tat/CD40L treated monocytes
Reddy et al., Cell Immunol 2007 : CNTO 1275 inhibited upregulation of CLA, IL-12R, IL-2Ralpha and CD40L expression and also inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A, tumor necrosis factor (TNF)-alpha , IL-2, and IL-10 secretion
Pignatelli et al., Cardiovasc Res 2008 (Heart Failure) : Also, an in vitro study was performed by determining platelet CD40L regulation upon platelet stimulation with TNFalpha ... The in vitro study demonstrated that TNFalpha significantly increased CD40L expression, an effect weakly influenced by aspirin but significantly reduced by AACOCF3, an inhibitor of PLA(2), apocynin, an inhibitor of NADPH oxidase, or staurosporine, an inhibitor of PKC
Kim et al., Biosci Biotechnol Biochem 2008 (Bone Resorption...) : Furthermore, TNF-alpha induced TRAP activity was greatly inhibited by YSP ( 100 microg/ml ) treatment
Lång et al., Histochem Cell Biol 2009 (Colitis) : Among these cytokines, TNFalpha up-regulated TRAP expression in the RAW 264.7 monocyte/macrophage cell line
da Silva et al., Immunobiology 2013 : CD40L did not stimulate the secretion of IL-10, IL-12, TNF-a or IFN-? and did not stimulate migration toward CCL19 or CCL21
Zhang et al., J Huazhong Univ Sci Technolog Med Sci 2012 : The stimulation of CD40+ glioma cells with soluble CD40L ( CD154 ) up-regulated the expression of TNF-a at both mRNA and protein levels
Ramsdell et al., J Immunol 1994 : In addition to proliferation, CD40L induces lectin mediated cytolytic activity in thymic gamma delta T cells as well as the production of IFN-gamma and TNF-alpha
Gruss et al., Eur J Immunol 1995 (Hodgkin Disease) : We have found that both the recombinant CD30L and CD40L enhanced interleukin (IL)-6, TNF and lymphotoxin (LT)-alpha release from cultured H-RS cells
Cheng et al., Genes Dev 1996 : TANK, a co-inducer with TRAF2 of TNF- and CD 40L mediated NF-kappaB activation
Sekine et al., J Rheumatol 1998 (Arthritis, Rheumatoid) : TNF-alpha secretion from RA SFMC was enhanced by CD40 ligand stimulation