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TP53 — VRK1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TP53 → VRK1 (increases, TP53 Activity) Vega et al., Mol Cell Biol 2004*
  Evidence: VRK1 is located in the nucleus outside the nucleolus. Overexpression of VRK1 increases the stability of p53 by a posttranslational mechanism leading to its accumulation Catalytically inactive VRK1 protein (a K179E mutant) does not induce p53 accumulation.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TP53 — VRK1 (direct interaction, enzymatic study) Lopez-Borges et al., Oncogene 2000*
• IRef Biogrid Interaction: TP53 — VRK1 (physical association, affinity chromatography technology) Vega et al., Mol Cell Biol 2004*
• IRef Biogrid Interaction: TP53 — VRK1 (direct interaction, enzymatic study) Vega et al., Mol Cell Biol 2004*
• IRef Biogrid Interaction: TP53 — VRK1 (direct interaction, enzymatic study) Barcia et al., Arch Biochem Biophys 2002*
• IRef Hprd Interaction: TP53 — VRK1 (in vitro) Sayed et al., J Biol Chem 2000, Lopez-Borges et al., Oncogene 2000*, Latonen et al., Oncogene 2001*, Barcia et al., Arch Biochem Biophys 2002*
• IRef Hprd Interaction: TP53 — VRK1 (in vivo) Sayed et al., J Biol Chem 2000, Lopez-Borges et al., Oncogene 2000*, Latonen et al., Oncogene 2001*, Barcia et al., Arch Biochem Biophys 2002*
• IRef Intact Interaction: TP53 — VRK1 (colocalization, confocal microscopy) Vega et al., Mol Cell Biol 2004*

Text-mined interactions from Literome

Vega et al., Mol Cell Biol 2004 : Overexpression of VRK1 increases the stability of p53 by a posttranslational mechanism leading to its accumulation by a mechanism independent of the Chk2 kinase
Valbuena et al., PloS one 2008 : Downregulation of VRK1 induced by p53 is prevented in a dose dependent manner by either p300 or CBP, but not by PCAF, used as transcriptional co-activators, suggesting that p53 has a different specificity depending on the relative level of these transcriptional cofactors ... Specifically, the downregulation of VRK1/VRK2 protein levels, as a consequence of p53 accumulation, is thus dependent on the levels of the p300/CBP protein available for transcriptional complexes, since in this context this cofactor functions as a repressor of the effect
Valbuena et al., PloS one 2011 : Human VRK1 induces a stabilization and accumulation of p53 by specific phosphorylation in Thr18