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EPHB2 — PTPN11

Text-mined interactions from Literome

Shi et al., Mol Cell Biol 2000 (MAP Kinase Signaling System) : To address the molecular mechanism for the positive role of Shp-2 in mediating Erk induction, we evaluated the activation of signaling components upstream of Erk in Shp-2 mutant cells
Cunnick et al., J Biol Chem 2000 : These results establish a role for Gab1 in the LPA induced MAP kinase pathway and clearly demonstrate that Gab1-SHP2 interaction is essential for ERK2 activation by LPA and EGF
Maroun et al., Mol Cell Biol 2000 : To elucidate the Gab1 dependent signals required for epithelial morphogenesis, we undertook a structure-function approach and demonstrate that association of Gab1 with the tyrosine phosphatase SHP-2 is required for sustained Erk activation and for epithelial morphogenesis downstream from the Met receptor
Cunnick et al., J Biol Chem 2001 : To investigate the mechanism by which Gab1 and SHP2 mediate ERK activation, we characterized the Gab1-SHP2 interaction ... Thus, physical association of activated SHP2 with Gab1 is necessary and sufficient to mediate the ERK mitogen activated protein kinase activation
Guillemot et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Taken together, these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region, both in a p21(ras)/Raf-1/MEK/ERK dependent manner, and also involves PI3K and SHP-2
Cunnick et al., J Biol Chem 2002 (MAP Kinase Signaling System) : We found that expression of a fusion protein consisting of the Gab1 PH domain and an active SHP2 ( Gab1PH-SHP2DeltaN ) induced constitutive Mek1 and Erk2 activation
Yu et al., J Biol Chem 2002 : SHP2 is shown to associate with and dephosphorylate Gab1, suggesting that EGF stimulated ERK might act through the regulation of SHP2
Chen et al., Dev Biol 2002 : Mutant ( but not wt ) SHP-2 expression also inhibited NGF stimulated ERK activation
MacGillivray et al., J Biol Chem 2003 (MAP Kinase Signaling System) : The protein tyrosine phosphatase SHP-2 regulates interleukin-1 induced ERK activation in fibroblasts
Araki et al., J Biol Chem 2003 : Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors ... The protein-tyrosine phosphatase Shp2 is required for normal activation of the ERK mitogen activated protein kinase in multiple receptor tyrosine kinase signaling pathways
Wheadon et al., Biochem J 2003 : However, expression of WT SHP-2 increased ERK ( extracellular-signal regulated kinase ) activation
Ruhul Amin et al., Cancer Res 2003 (MAP Kinase Signaling System) : Finally, reintroduction of wild-type SHP-2 into SHP-2 mutant cells rescued Erk and p38 activation, and also MMP-2 secretion, whereas dominant negative SHP-2 could block the Con A-dependent activation of Erk and p38
Higashi et al., J Biol Chem 2004 : Thus, SHP-2 acts as a positive regulator of Erk activity in AGS cells ... These results indicate that SHP-2 is involved in the Ras independent modification of Erk signals that is necessary for the morphogenetic activity of CagA
Zhang et al., Mol Cell 2004 : Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment
Arnaud et al., Biochem J 2004 (Leukemia, Prolymphocytic, T-Cell) : Expression of the Gab2 Tyr-614 -- > Phe ( Y614F ) mutant, defective in SHP-2 association, prevents ERK ( extracellular-signal regulated kinase ) activation and expression of a luciferase reporter plasmid driven by the c-fos SRE ( serum response element ), indicating that interaction of SHP-2 with Gab2 is required for ERK activation in response to IL-2
Maeda et al., Biochem Biophys Res Commun 2004 : Expression of Gab1 PI3K-m in SK-N-MC human primitive neuroectodermal tumor cells expressing wild-type RET markedly impaired Akt phosphorylation, Rac1 activation, and lamellipodia formation that were induced by GDNF whereas expression of Gab1 SHP2-m partially impaired Erk activation
Arnaud et al., J Immunol 2004 (MAP Kinase Signaling System) : We report that pretreatment of Kit 225 cells with U0126 increased Gab2/SHP-2 association and tyrosine phosphorylation of SHP-2 in response to IL-2, suggesting that ERK phosphorylation of serine 623 regulates the interaction between Gab2 and SHP-2 , and consequently the activity of SHP-2
Peek et al., Science's STKE : signal transduction knowledge environment 2005 (Adenocarcinoma...) : Higashi et al. now demonstrate that CagA dependent SHP-2 activation leads to sustained activation of ERK ( extracellular signal regulated kinase ), culminating in morphological changes that mimic unrestrained stimulation by growth factors
Pai et al., Biochem Biophys Res Commun 2005 (Stomach Neoplasms) : While JAK inhibition with AG490 significantly reduced leptin induced ERK2 , STAT3 phosphorylation, and cell proliferation, SHP2 inhibition only partially reduced cancer cell proliferation
He et al., Zhonghua Bing Li Xue Za Zhi 2005 (Neoplasm Invasiveness...) : Both SHP2 and MKP5 play some roles in P2Y receptor mediated activation of MEK/ERK , p38 signaling pathways and prostate cancer invasion ... SHP2 positively regulates ERK activation and prostate cancer invasion, whereas MKP5 inhibits the invasion by suppressing p38 activation
Simoncic et al., Mol Cell Biol 2006 : Tcptp-/- macrophages also have increased tyrosine phosphorylation and recruitment of a Grb2/Gab2/Shp2 complex to the CSF-1R and enhanced activation of Erk after CSF-1 stimulation, which are important molecular events in CSF-1 induced differentiation
Sarmiento et al., Biochim Biophys Acta 2008 (Pancreatitis) : Inhibition of JNK and ERK1/2 with SP600125 pre-treatment further increased the expression of both SHP-1 and SHP-2 proteins in the early phase of Cer induced AP, while the inhibition of type IV phosphodiesterase with rolipram only suppressed the increase in SHP-2 protein expression during the same phase
Zhou et al., Cell Death Differ 2008 (Breast Neoplasms...) : Inhibition of SHP2 suppressed EGF induced activation of the Ras-ERK and the phosphatidylinositol 3 kinase-Akt signaling pathways, abolished anchorage independent growth, induced epithelial cell morphology and led to reversion to a normal breast epithelial phenotype
Mitra et al., J Cell Sci 2008 : Significantly, we demonstrate that phosphorylation of SHP-2 on Y279 downregulates growth factor induced sustained ERK activation and proliferation, supporting a role for Abl kinases not only in potentiating growth factor mediated SHP-2 signaling, but also in negative-feedback regulation
Hale et al., Virology 2009 : Our data suggest that CDK/ERK mediated phosphorylation of NS1 at threonine-215 is important for efficient virus replication
Tashiro et al., J Biol Chem 2009 : Because the amino acid sequence surrounding tyrosine 453 is similar to the immunoreceptor tyrosine based inhibitory motif, Shp2 , a positive regulator of Erk , binds to GAREM in this phosphorylation dependent manner
Jack et al., Blood 2009 (MAP Kinase Signaling System) : SHP2 inhibition reduced ERK activation in G-CSF, but not M-CSF, and reduced colony forming unit-granulocytes, underscoring divergent pathways to ERK activation
Lennartsson et al., Cell Signal 2010 : We could also demonstrate that Shp2 docking to the receptor is critical for Src kinase activation, suggesting that Shp2 may contribute to Erk5 activation through its involvement in Src kinase activation
Wang et al., J Biol Chem 2010 : Interactions between SHP-2 and PTPalpha, recruitment of SHP-2 to focal adhesions, IL-1 induced ERK activation , and MMP3 expression were all blocked by point mutations in the phosphatase domains of PTPalpha
Stewart et al., Dev Cell 2010 (LEOPARD Syndrome...) : By comparing shp2-deficient zebrafish embryos with those injected with mRNA encoding LEOPARD syndrome point mutations, we identify a phosphatase- and Erk dependent role for Shp2 in neural crest specification and migration
Zhang et al., Blood 2011 (MAP Kinase Signaling System) : In summary, SHP2 is required for induction of C/EBPa expression and granulopoiesis in response to G-CSF or other cytokines independent of SHP2 mediated ERK activation
Puri et al., Biol Reprod 2013 : The overexpression of a constitutive active SHP2 mutant, SHP2 Q79R, up-regulated the BTB disruptor ERK1/2 via Src kinase in primary rat Sertoli cells in culture
Takahashi-Tezuka et al., Mol Cell Biol 1998 : These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that SHP-2 , PI-3 kinase, and Ras are involved in Gab1 mediated ERK activation
Florio et al., Mol Endocrinol 1999 : We show that the activation of ERK via SSTR1 is pertussis toxin sensitive and requires the small G protein Ras, phosphatidylinositol 3-kinase, the serine/threonine kinase Raf-1, and the protein tyrosine phosphatase SHP-2