Bhattacharyya et al., J Biol Chem 2008
(Inflammation) :
The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 ( B-cell CLL/lymphoma 10 ) ... Additional experiments with TLR4 blocking antibody and TLR4 small interfering RNAs showed 80 % reductions in CGN induced increases in Bcl10 and IL-8 Bhattacharyya et al., Biochim Biophys Acta 2008
:
The combination of ROS quenching by the free radical scavenger Tempol and of Bcl10 silencing by siRNA completely inhibited the CGN induced increases in nuclear NFkappaB ( p65 ), phospho-IkappaBalpha, and secretion of IL-8