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MYLIP — ZEB1

Text-mined interactions from Literome

Hurteau et al., Cancer Res 2007 (Neoplasm Invasiveness) : Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin ... Stable overexpression of miR-200c in A549 cells results in a loss of TCF8 , an increase in expression of its regulatory target, E-cadherin, and altered cell morphology ... The ectopic expression of miR-200c in this cell line also reduced levels of TCF8 , restored E-cadherin expression, and altered cell morphology
Adam et al., Clin Cancer Res 2009 (Carcinoma...) : Stable expression of miR-200 in mesenchymal UMUC3 cells increased E-cadherin levels, decreased expression of ZEB1, ZEB2 , ERRFI-1, and cell migration, and increased sensitivity to EGFR blocking agents
Wellner et al., Nat Cell Biol 2009 (Neoplasms) : We show that ZEB1 represses expression of stemness inhibiting miR-203 and that candidate targets of miR-200 family members are also stem cell factors, such as Sox2 and Klf4
Siemens et al., Cell cycle (Georgetown, Tex.) 2011 : miR-34a also down-regulated SLUG and ZEB1 , as well as the stemness factors BMI1, CD44, CD133, OLFM4 and c-MYC ... Conversely, the transcription factors SNAIL and ZEB1 bound to E-boxes in the miR-34a/b/c promoters, thereby repressing miR-34a and miR-34b/c expression
Putta et al., J Am Soc Nephrol 2012 (Albuminuria...) : In the kidneys of diabetic mice, inhibition of miR-192 significantly increased Zeb1/2 and decreased gene expression of collagen, TGF-ß, and fibronectin ; immunostaining confirmed the downregulation of these mediators of renal fibrosis
Ono et al., Oncogene 2012 (Colorectal Neoplasms) : Taken together, SIX1 overexpression is suggested to occur in carcinogenesis, and contribute to repression of CDH1 expression and promotion of EMT partly through repression of miR-200-family expression and activation of ZEB1 in CRC
Tran et al., J Biol Chem 2013 (Urinary Bladder Neoplasms) : Stable knockdown of dNp63a in the `` epithelial '' bladder cancer cell line UM-UC6 decreased the expression of miR-205 and induced the expression of ZEB1/2 , effects that were reversed by expression of exogenous miR-205
DeCastro et al., Cell death & disease 2013 : In addition, we present evidence that the transcription factor Zeb1 represses miR203 expression, thus enhancing dNp63a protein levels
Cai et al., Cell Biol Int 2013 : Bioinformatic analysis and Western blot showed that ZEB1 was directly suppressed by miR-200b
Renthal et al., Nat Rev Endocrinol 2013 : This article reviews the actions of the miR-200 family and their P4-regulated targets-the transcription factors ZEB1, ZEB2 and STAT5B-in the pregnant myometrium, as well as the role of miR-199a-3p and miR-214 and their mutual target PTGS2
Chen et al., Journal of ovarian research 2013 : However, the stable overexpression of the miR-200c in the CD117+CD44+CSCs resulted in a significant down-regulation of ZEB-1 and the Vimentin expression, an upregulation of the E-cadherin expression as well as a decrease of colony forming, migratory and invasion in vitro