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SMURF2 — TNF

Text-mined interactions from Literome

Kaneki et al., J Biol Chem 2006 : We treated C2C12 and 2T3 osteoblast precursor cell lines and primary osteoblasts with TNF and found that TNF , but not interleukin-1, significantly increased Smurf1 and Smurf2 expression
He et al., PloS one 2012 (Inflammation...) : TNF-a also induces the expression of E3 ubiquitin ligase protein Smurf1 and Smurf2 and promotes degradation of Runx2, another key transcription factor regulating osteoblast differentiation and bone formation