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APP — MAPK8IP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
MAPK8IP1
—
APP
Scheinfeld et al., J Biol Chem 2002*
-
IRef Bind_translation Interaction:
MAPK8IP1
—
APP
(fluorescent resonance energy transfer)
Scheinfeld et al., J Biol Chem 2002*
-
IRef Bind_translation Interaction:
MAPK8IP1
—
APP
(coimmunoprecipitation)
Scheinfeld et al., J Biol Chem 2002*
-
IRef Bind_translation Interaction:
MAPK8IP1
—
APP
(affinity chromatography technology)
Scheinfeld et al., J Biol Chem 2002*
-
IRef Bind_translation Interaction:
MAPK8IP1
—
APP
(two hybrid)
Scheinfeld et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
MAPK8IP1
—
APP
(direct interaction, two hybrid)
Kajiwara et al., Molecular neurodegeneration 2010
-
IRef Biogrid Interaction:
MAPK8IP1
—
APP
(direct interaction, pull down)
Scheinfeld et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
MAPK8IP1
—
APP
(direct interaction, enzymatic study)
Scheinfeld et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
MAPK8IP1
—
APP
(physical association, affinity chromatography technology)
Muresan et al., J Cell Biol 2005*
-
IRef Hprd Interaction:
Complex of APP-KLC1-APP-MAPK8IP1-MAPK8IP1-KLC1-APP-MAPK8IP1-KLC1
(in vivo)
Matsuda et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
APP
—
MAPK8IP1
(two hybrid)
Matsuda et al., J Neurosci 2001*, Scheinfeld et al., J Biol Chem 2002*, Matsuda et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
APP
—
MAPK8IP1
(in vitro)
Matsuda et al., J Neurosci 2001*, Scheinfeld et al., J Biol Chem 2002*, Matsuda et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
APP
—
MAPK8IP1
(in vivo)
Matsuda et al., J Neurosci 2001*, Scheinfeld et al., J Biol Chem 2002*, Matsuda et al., J Biol Chem 2003*
-
IRef Innatedb Interaction:
Complex of MAP3K11-MAPK8IP1-APP
(unknown, -)
Scheinfeld et al., J Biol Chem 2003*
-
IRef Innatedb Interaction:
Complex of APP-MAPK8IP1-MAPK8
(unknown, -)
Scheinfeld et al., J Biol Chem 2003*
-
IRef Innatedb Interaction:
MAPK8IP1
—
APP
(unknown, -)
Scheinfeld et al., J Biol Chem 2003*
-
IRef Intact Interaction:
MAPK8IP1
—
APP
(direct interaction, fluorescent resonance energy transfer)
Scheinfeld et al., J Biol Chem 2002*
-
IRef Intact Interaction:
MAPK8IP1
—
APP
(physical association, pull down)
Scheinfeld et al., J Biol Chem 2002*
-
IRef Intact Interaction:
MAPK8IP1
—
APP
(physical association, two hybrid)
Scheinfeld et al., J Biol Chem 2002*
-
IRef Intact Interaction:
MAPK8IP1
—
APP
(physical association, anti tag coimmunoprecipitation)
Scheinfeld et al., J Biol Chem 2002*
-
IRef Ophid Interaction:
MAPK8IP1
—
APP
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
MAPK8IP1
—
APP
(aggregation, confirmational text mining)
Scheinfeld et al., J Biol Chem 2002*
Text-mined interactions from Literome
Matsuda et al., J Neurosci 2001
(Alzheimer Disease) :
The
APP amino acids Tyr ( 682 ), Asn ( 684 ), and Tyr ( 687 ) in the G ( 681 ) YENPTY ( 687 ) region were all
essential for
APP/JIP-1b interaction, but neither Tyr ( 653 ) nor Thr ( 668 ) was necessary ... Moreover, human JNK1beta1 formed a complex with
APP in a
JIP-1b dependent manner
Taru et al., J Biol Chem 2002
(Alzheimer Disease) :
Overexpression of
JIP1b slightly
enhances the JNK dependent threonine phosphorylation of
APP in cultured cells, but that of JIP2 suppresses it
Taru et al., J Biol Chem 2002
:
The expression of
JIP1b stabilizes immature
APP and suppresses the production of a secreted large extracellular amino-terminal domain of APP, the generation of a cleaved intracellular carboxyl-terminal fragment of APP, and the secretion of beta-amyloid 40 and 42
Inomata et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
In this study, we isolated JIP-1b, a JNK signaling scaffold protein, as a binding protein of APP, and analyzed the
roles of
JIP-1b in APP phosphorylation by JNK and the association of kinesin light chain 1 with
APP ...
JIP-1b also
enhanced the association of kinesin light chain 1 with
APP
Muresan et al., J Cell Biol 2005
:
These results indicate that the phosphorylation of
APP regulates the formation of a
pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP