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PCSK1 — STAT3
Text-mined interactions from Literome
Fox et al., Mol Endocrinol 2008
:
Studies herein reveal that leptin induced
PC1/3 gene expression is abrogated in N2KO mice, and that in a hypothalamic cell line both
STAT3 and Nhlh2 are
required for the full transcriptional response of a PC1/3 reporter gene after leptin stimulation
Talbot et al., Proc Natl Acad Sci U S A 2011
(Disease Models, Animal...) :
Here we show that membrane anchored
PC1 activates
STAT3 in a JAK2 dependent manner, leading to tyrosine phosphorylation and transcriptional activity ... These results indicate that
STAT3 signaling is
regulated by
PC1 and is a driving factor for renal epithelial proliferation during normal renal development and during cyst growth