◀ Back to IL10
CXCR4 — IL10
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CXCR4
→
IL10
(decreases, IL10 Translocation)
Wang et al., J Biol Chem 2001*
Evidence: and up-regulated by IL-10 and transforming growth factor-beta 1. Down-regulation was mediated post-translationally, in the absence of protein degradation, through an endocytotic mechanism.
Text-mined interactions from Literome
Jinquan et al., Immunology 2000
(Inflammation) :
The
regulation of
CXCR4 expression in CD4+ T lymphocytes by IL-4 and
IL-10 could be blocked by a selective inhibitor of protein kinase ( staurosporine ) or by a selective inhibitor of cAMP- and cGMP dependent protein kinase ( H-8 ), indicating that these cytokines regulate CXCR4 on CD4+ T lymphocytes via both cAMP and cGMP signalling pathways
Wilson et al., Infect Immun 1995
(Leishmaniasis, Visceral) :
Recombinant
Lcr1 , cloned adjacent to polyhistidine and purified on a nickel affinity column,
stimulated gamma interferon but not interleukin-4 (IL-4), IL-5, or
IL-10 secretion by T-cell enriched splenocytes from either susceptible or resistant mice during L. chagasi infection