◀ Back to MAPK8
MAP3K5 — MAPK8
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MAPK8
→
MAP3K5
(increases, MAP3K5 Activity, MAPK8 Activity)
Evidence: Modified assertion
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OpenBEL Selventa BEL large corpus:
MAPK8
→
MAP3K5
(increases, MAP3K5 Activity, MAPK8 Activity)
Evidence: Figure 4 Anti-apoptotic brakes at the mitochondrion. Black lines represent apoptotic pathways, red lines indicate inhibition. BCL2 (B-cell leukaemia lymphoma-2) and ?B-crystallin prevent mitochondrial release of the apoptogenic factors AIF (apoptosisinducing factor), cytochrome c (cyto c), HTRA2/OMI (high temperature requirement serine protease 2) and SMAC/DIABLO (second-mitochondrial-derived activator of caspases) into the cytosol by the binding and sequestration of BAX (B-cell lymphoma 2-assoc...
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WikiPathways Apoptosis Modulation and Signaling:
MAP3K5
→
MAPK8
(activation)
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WikiPathways Corticotropin-releasing hormone signaling pathway:
MAP3K5
→
MAPK8
(activation)
Text-mined interactions from Literome
Korchnak et al., Cell Signal 2009
:
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (
MAP3K ) that
activates multiple mitogen activated protein kinase (
MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Wu et al., Free Radic Biol Med 2010
(Drug-Induced Liver Injury) :
These studies show that TNFalpha
increases oxidative stress in mice with elevated CYP2E1, with subsequent activation of
ASK-1 via a mechanism involving thioredoxin-ASK-1 dissociation, followed by activation of downstream MKK and
MAPK