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CDC6 — MCM10

Pathways - manually collected, often from reviews:

• Reactome Reaction: CDC6 → MCM10 (reaction) Izumi et al., Nucleic Acids Res 2000
• Reactome Reaction: CDC6 → MCM10 (indirect_complex) Izumi et al., Nucleic Acids Res 2000

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: MCM10 — CDC6 Ramachandran et al., Science 2004
• IRef Bind_translation Interaction: MCM10 — CDC6 (array technology) Ramachandran et al., Science 2004
• IRef Biogrid Interaction: MCM10 — CDC6 (direct interaction, pull down) Ramachandran et al., Science 2004
• IRef Hprd Interaction: MCM10 — CDC6 (in vitro) Ramachandran et al., Science 2004
• IRef Intact Interaction: MCM10 — CDC6 (direct interaction, protein array) Ramachandran et al., Science 2004
• IRef Ophid Interaction: MCM10 — CDC6 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: MCM10 — CDC6 (aggregation, confirmational text mining) Ramachandran et al., Science 2004

Text-mined interactions from Literome

Van Hatten et al., J Cell Biol 2002 : Mini-chromosome maintenance (MCM)2-7 recruitment to origins in G1 requires origin recognition complex (ORC), Cdt1, and Cdc6 , and activation at G1/S requires MCM10 and the protein kinases Cdc7 and S-Cdk, which together recruit Cdc45, a putative MCM2-7 cofactor required for origin unwinding
Ricke et al., J Biol Chem 2006 : These results are consistent with Mcm10 having a role as a nuclear chaperone for Cdc17. Mutational analysis indicates that a conserved heat-shock protein 10 (Hsp10)-like domain in Mcm10 is required to prevent the degradation of Cdc17. Substitution of a single residue in the Hsp10-like domain of endogenous Mcm10 results in a dramatic reduction of steady-state Cdc17 levels