UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to HLA-DRB1

CD28 — HLA-DRB1

Pathways - manually collected, often from reviews:

NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, collaborate)
Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
Evidence: mutant phenotype, assay
NCI Pathway Database TCR signaling in naïve CD4+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, activates)
Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
Evidence: mutant phenotype, assay
NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, activates)
Woods et al., EMBO J 2001, Wilcox et al., J Biol Chem 2003, August et al., Proc Natl Acad Sci U S A 1994, Raab et al., Proc Natl Acad Sci U S A 1995, Gibson et al., J Biol Chem 1996, Heyeck et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD4+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, activates)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
Evidence: mutant phenotype, assay
NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, activates)
Raab et al., Proc Natl Acad Sci U S A 1995
Evidence: mutant phenotype, assay