◀ Back to PLAT
MMP10 — PLAT
Text-mined interactions from Literome
Mishiro et al., Neuroscience 2012
(Cerebral Hemorrhage...) :
We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle, delayed tPA alone, or combined
tPA ( 10 mg/kg, i.v. ) plus GM6001 ( 100 mg/kg, i.p. ), a broad-spectrum
MMP inhibitor
Lakhan et al., Frontiers in neurology 2013
:
Reactive oxygen species can enhance the
effects of
tPA on
MMP activation through the loss of caveolin-1 ( cav-1 ), a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability
Kolben et al., Eur J Obstet Gynecol Reprod Biol 1996
(HELLP Syndrome...) :
In HELLP syndrome,
tPA and TIMP-1 are also elevated, and in patients with hpD,
MMP-8 is
increased , whereas MMP-9, and TIMP-1 are lower