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CD4 — IL1A

Text-mined interactions from Literome

Hata et al., J Clin Invest 2004 (Arthritis, Experimental...) : Thus, IL-6, IL-1 , TNF-alpha, and IL-10 play distinct roles in the development of SKG arthritis ; arthritogenic CD4 ( + ) T cells are not required to skew to either Th1 or Th2 ; and the appearance of rheumatoid factor is independent of joint inflammation
Merrill et al., J Virol 1992 : Soluble recombinant CD4 did not block TNF alpha and IL-1 production
Ciolli et al., J Exp Med 1991 (Leukemia, Erythroblastic, Acute...) : These data indicate that in mice injected with FLC, the antitumor effects of IL-1/IL-2 are mediated by CD4+ and CD8+ cells ( but not NK cells ), and suggest that this combined cytokine treatment may be effective against established metastatic tumors
Ather et al., J Immunol 2011 (Disease Models, Animal...) : CD4 ( + ) T cells polyclonally stimulated in the presence of conditioned media from SAA exposed DCs produced IL-17, and the capacity of polyclonally stimulated splenocytes to secrete IL-17 is dependent upon IL-1 , TLR2, and the NLRP3 inflammasome
Koide et al., J Exp Med 1988 : Induction of the IL-1 alpha gene seemed to require the recognition of class II MHC products on the macrophage because of the following observations : specific rather than third-party macrophages were responsive to the T blast but not to T cell conditioned media ; induction was blocked by an anti-Ia mAb ; CD4+ rather than CD8+ blasts were active ; and polyclonal Con A blasts were much less efficient than antigen-specific T cells
Wrenshall et al., Hum Immunol 1993 : Regulation by heparan sulfate and interleukin 1 alpha of the ontogenic expression of T-cell receptor, CD4 , and CD8 in developing thymus
Yu et al., Neuroimmunomodulation 1998 : IL-1-alpha and TNF-alpha differentially regulate CD4 and Mac-1 expression in mouse microglia