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FGF2 — PCSK1
Text-mined interactions from Literome
Hatch et al., Connect Tissue Res 2005
(Craniosynostoses) :
FGF2 specifically
induced expression of
PC-1 and ANK while inhibiting expression of TNAP, at both mRNA and protein levels
Hatch et al., Orthod Craniofac Res 2007
(Craniosynostoses) :
Towards this goal we have constructed a PC-1 gene promoter/firefly luciferase reporter construct, in order to more directly investigate the
regulation of
PC-1 by
FGF/FGFR signaling in osteoblastic and non-osteoblastic cells ... Preliminary results confirm that
FGF/FGFR signaling, either via treatment with FGF2 or via expression of a Crouzon syndrome associated mutant FGFR2,
induces PC-1 promoter activity in osteoblastic cells in culture
Hatch et al., Cells Tissues Organs 2009
:
We previously showed that
FGF2 induces
PC-1 expression in preosteoblastic cells and that this induction is differentiation stage dependent
Hatch et al., J Bone Miner Res 2009
:
We previously showed that
fibroblast growth factor 2 (FGF2) induces
PC-1 and Ank while inhibiting Tnap expression and mineralization in MC3T3E1 ( C4 ) calvarial pre-osteoblast cells ... Specifically,
FGF2 was unable to
induce PC-1 expression in Runx2 negative nonbone cells or in calvarial cells from Runx2-deficient mice ... Taken together, our results establish that
FGF2 is a specific
inducer of
PC-1 in pre-osteoblast cells and that FGF2 induces PC-1 expression through a mechanism involving Runx2
Li et al., J Cell Biochem 2010
:
We previously showed that
fibroblast growth factor-2 (FGF2) specifically
induces PC-1 expression in calvarial pre-osteoblasts and that this occurs via a transcriptional mechanism involving Runx2
Solan et al., J Bone Miner Res 1996
(Osteosarcoma) :
Expression of the nucleoside triphosphate pyrophosphohydrolase
PC-1 is
induced by
basic fibroblast growth factor (bFGF) and modulated by activation of the protein kinase A and C pathways in osteoblast-like osteosarcoma cells ... We observed that
bFGF induced expression of
PC-1 , a member of the NTPPPH gene family