Gene interactions and pathways from curated databases and text-mining

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FGF2 — PCSK1

Text-mined interactions from Literome

Hatch et al., Connect Tissue Res 2005 (Craniosynostoses) : FGF2 specifically induced expression of PC-1 and ANK while inhibiting expression of TNAP, at both mRNA and protein levels
Hatch et al., Orthod Craniofac Res 2007 (Craniosynostoses) : Towards this goal we have constructed a PC-1 gene promoter/firefly luciferase reporter construct, in order to more directly investigate the regulation of PC-1 by FGF/FGFR signaling in osteoblastic and non-osteoblastic cells ... Preliminary results confirm that FGF/FGFR signaling, either via treatment with FGF2 or via expression of a Crouzon syndrome associated mutant FGFR2, induces PC-1 promoter activity in osteoblastic cells in culture
Hatch et al., Cells Tissues Organs 2009 : We previously showed that FGF2 induces PC-1 expression in preosteoblastic cells and that this induction is differentiation stage dependent
Hatch et al., J Bone Miner Res 2009 : We previously showed that fibroblast growth factor 2 (FGF2) induces PC-1 and Ank while inhibiting Tnap expression and mineralization in MC3T3E1 ( C4 ) calvarial pre-osteoblast cells ... Specifically, FGF2 was unable to induce PC-1 expression in Runx2 negative nonbone cells or in calvarial cells from Runx2-deficient mice ... Taken together, our results establish that FGF2 is a specific inducer of PC-1 in pre-osteoblast cells and that FGF2 induces PC-1 expression through a mechanism involving Runx2
Li et al., J Cell Biochem 2010 : We previously showed that fibroblast growth factor-2 (FGF2) specifically induces PC-1 expression in calvarial pre-osteoblasts and that this occurs via a transcriptional mechanism involving Runx2
Solan et al., J Bone Miner Res 1996 (Osteosarcoma) : Expression of the nucleoside triphosphate pyrophosphohydrolase PC-1 is induced by basic fibroblast growth factor (bFGF) and modulated by activation of the protein kinase A and C pathways in osteoblast-like osteosarcoma cells ... We observed that bFGF induced expression of PC-1 , a member of the NTPPPH gene family