Ribeiro et al., J Biol Chem 2009
:
Expression of a catalytically inactive GRK2-K220R mutant also effectively attenuates mGluR5 signaling, but the expression of a GRK2-D110A mutant devoid in Galpha ( q/11 ) binding increases mGluR5 signaling in response to agonist stimulation
Zhang et al., Mol Biol (Mosk) 2013
:
However, whether GRK2 mediated mGluR5 desensitization is phosphorylation dependent remains controversial