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FRS2 — MAPK1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
FRS2
→
MAPK1
(directlyIncreases, FRS2 Activity)
Wu et al., Biol Chem 2003
Evidence: These results indicate a ligand-stimulated negative regulatory feedback loop in which activated ERK1/2 phosphorylates FRS2 on serine/threonine residues thereby down-regulating its tyrosine phosphorylation.
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OpenBEL Selventa BEL large corpus:
FRS2
→
MAPK1
(directlyIncreases, FRS2 Activity)
Wu et al., Biol Chem 2003
Evidence: This migration shift of FRS2 is completely abrogated by U0126, a specific MAPK kinase 1 (MEK1) inhibitor, suggesting that ERK1/2 acts as serine/threonine kinase upstream of FRS2.
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NCI Pathway Database FGF signaling pathway:
Erk1-2-active (MAPK3/MAPK1)
→
FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2)
(modification, activates)
Lax et al., Mol Cell 2002
Evidence: mutant phenotype, other species
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Reactome Reaction:
MAPK1
→
FRS2
(reaction)
Lax et al., Mol Cell 2002, Wu et al., Biol Chem 2003, Gotoh et al., Cancer Sci 2008, Zhou et al., Cell Res 2009
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kornmann et al., Gastroenterology 2002
(Cell Transformation, Neoplastic...) :
In vitro, TAKA-1 cells stably transfected with FGFR-1 IIIc exhibited increased basal growth ; enhanced basal tyrosine phosphorylation of
FGFR substrate-2 (FRS2) , Shc, and phospholipase Cgamma ; and increased
activation of mitogen activated protein kinase (
MAPK )
Wu et al., Biol Chem 2003
:
Upon EGF stimulation,
FRS2 mediates enhanced
MAPK activity and undergoes phosphorylation on tyrosine as well as serine/threonine residues ... Upon EGF stimulation,
FRS2 mediates enhanced
MAPK activity and undergoes phosphorylation on tyrosine as well as serine/threonine residues
Yokote et al., Proc Natl Acad Sci U S A 2005
:
Moreover, both receptors stimulate tyrosine phosphorylation of the docking protein
FRS2alpha and
induce mitogen activated protein kinase stimulation with a time course and intensity that depends on the ligand that is applied
Easton et al., J Neurochem 2006
(Neuroblastoma) :
In addition to Shc, fibroblast growth
factor receptor substrate 2 (FRS2) is
required for the BDNF induced activation of
MAPK