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CDC7 — CDK2

Pathways - manually collected, often from reviews:

• Reactome Reaction: CDC7 → CDK2 (reaction) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999
• Reactome Reaction: CDC7 → CDK2 (indirect_complex) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDC7 — CDK2 (direct interaction, enzymatic study) Masai et al., J Biol Chem 2000
• IRef Biogrid Interaction: CDC7 — CDK2 (physical association, affinity chromatography technology) Martin et al., J Biochem Mol Biol 2007*
• IRef Biogrid Interaction: CDC7 — CDK2 (direct interaction, enzymatic study) Martin et al., J Biochem Mol Biol 2007*
• IRef Hprd Interaction: CDK2 — CDC7 (in vitro) Masai et al., J Biol Chem 2000

Text-mined interactions from Literome

Heo et al., Curr Genet 1999 : Hence, SCC1/MCD1/RHC21 is positively regulated by the mitotic CDK , CDC28
Wan et al., Genes Dev 2008 : CDK-S and DDK phosphorylation of Mer2 S30 and S29 can be bypassed by phosphomimetic amino acids, but break formation under these conditions is still dependent on DDK and CDK-S activity
Chuang et al., Mol Cell 2009 : These results are consistent with a role for cyclin E-Cdk2 in promoting the accumulation of Cdc6 and Cdc7 , which is required for Mcm2 loading when cells re-enter the cell cycle from quiescence
Cocklin et al., PloS one 2011 : Cell division is controlled in part by the timely activation of the CDK , Cdc28 , through its association with G1 and G2 cyclins
Jallepalli et al., Genes Dev 1996 : Rum1 and Cdc18 link inhibition of cyclin dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe
Sutton et al., Genetics 1997 : The CAK1 gene encodes the major CDK activating kinase (CAK) in budding yeast and is required for activation of Cdc28p for cell cycle progression from G2 to M phase