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CDKN1A — EGR1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ragione et al., J Biol Chem 2003
:
In conclusion, this is the first demonstration that
Egr1 controls
p21Cip1 expression by directly interacting with a specific sequence on its gene promoter
Choi et al., Cancer Res 2008
(Glioma) :
p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells :
role of
early growth response-1 expression ... Here, we report that transcription of the
p21 ( Waf1/Cip1 ) gene is
activated by
early growth response-1 (Egr-1) independently of p53 in response to curcumin treatment in U-87MG human glioblastoma cells
Shin et al., Exp Mol Med 2010
(Glioma) :
Forced expression of
Egr-1 enhanced
p21 ( Waf1/Cip1 ) promoter activity ... Finally, stable silencing of
Egr-1 expression
lead to attenuated CPZ-inducible
p21 ( Waf1/Cip1 ) expression and inhibited G2/M phase cell-cycle arrest
Besancenot et al., PLoS Biol 2010
:
Here, we show that TPO induces cell-cycle arrest in the megakaryocytic UT7-MPL cell line by the
activation of the ERK/MAPK pathway, induction of
p21CIP transcription, and senescence markers through
EGR1 activation
Parra et al., Oncol Rep 2013
:
Here, we report that transcription of the
p21Waf1/Cip1 and JNK-1 genes is
affected by inhibition of the
early growth response-1 (Egr-1) in response to a small interfering RNA [ siRNA ) -Egr-1 ] in LNCaP and PC-3 prostate carcinoma cell lines