Li et al., Oncogene 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Sphingosine kinase-1 mediates BCR/ABL induced upregulation of Mcl-1 in chronic myeloid leukemia cells
Li et al., Br J Haematol 2007
(Multiple Myeloma) :
IL-6 stimulation or retroviral mediated overexpression of SPHK1 in MM cells resulted in increased intracellular SPHK activity and upregulation of myeloid cell leukaemia-1 (Mcl-1) , leading to increased cell proliferation and survival ... Conversely, inhibition of SPHK1 by small interfering RNA reduced IL-6 induced upregulation of Mcl-1 and blocked the suppressive effect of IL-6 on MM cell apoptosis