◀ Back to SIRT1
ELAVL1 — SIRT1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Abdelmohsen et al., Mol Cell 2007
:
Phosphorylation of
HuR by Chk2
regulates SIRT1 expression ... Here, we report that
HuR associated with the 3 ' untranslated region of the mRNA encoding the longevity and stress-response protein SIRT1, stabilized the SIRT1 mRNA, and
increased SIRT1 expression levels ... Our findings demonstrate that
HuR regulates
SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes
Yamakuchi et al., Frontiers in physiology 2012
:
The background of SIRT1 and miRNAs will be summarized, followed by the mechanism by which several key miRNAs alter SIRT1 levels, and how the RBP
HuR regulates
SIRT1