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AKT2 — TSC1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
TSC1
—
AKT2
(interaction, mapped from grid)
-
STRING interaction:
TSC1
—
AKT2
(interaction, mapped from grid)
-
STRING interaction:
AKT2
—
TSC1
(interaction, mapped from grid bind mint)
-
STRING interaction:
AKT2
—
TSC1
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Potter et al., Nat Cell Biol 2002
:
Stimulating
Akt/PKB signalling in vivo markedly
increases cell growth/size, disrupts the Tsc1-Tsc2 complex and disturbs the distinct subcellular localization of
Tsc1 and Tsc2
Potter et al., Biochem Soc Trans 2003
:
We have shown that
Akt regulates the
Tsc1-Tsc2 complex by directly phosphorylating Tsc2
Dan et al., J Immunol 2008
:
mTOR is negatively controlled by the
tuberous sclerosis complex 1/2 (TSC1/2) , and activation of
Akt induces phosphorylation of TSC2, which blocks the repressive TSC1/2 activity
Pollizzi et al., Molecular cancer 2009
(Disease Models, Animal...) :
Loss of either
TSC1 or TSC2 in TSC hamartomas
leads to activation of mTORC1 and suppression of
AKT
Zhang et al., PloS one 2009
:
Loss of function of the
TSC1-TSC2 complex results in constitutive mTORC1 signaling and, through mTORC1 dependent feedback mechanisms and loss of mTORC2 activity,
leads to a concomitant block of
Akt signaling to its other downstream targets
Vadlakonda et al., Frontiers in oncology 2013
:
Akt phosphorylated at T308
inhibits TSC1/2 complex to activate mTORC1 ; mTORC2 is recognized as the kinase phosphorylating Akt at S473