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IL6 — SMAD3
Text-mined interactions from Literome
Verrecchia et al., J Biol Chem 2003
:
We demonstrate that, in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ),
interleukin-1 and tumor necrosis factor-alpha (TNF-alpha) did not
inhibit the formation of SMAD-DNA complexes and the resulting
SMAD-driven transcription in response to TGF-beta
Park et al., Oncogene 2003
(Prostatic Neoplasms) :
TGF-beta1 induced
IL-6 gene expression was strongly
inhibited by DN-Smad2 but not by
DN-Smad3 while it was further activated by wild-type Smad2 transfection
Feinberg et al., J Biol Chem 2004
(Arteriosclerosis...) :
Adenoviral overexpression of
Smad3 potently
repressed inducible expression of endogenous iNOS and
IL-6
Zhang et al., J Biol Chem 2005
:
These results indicate that
IL-6 increased trafficking of TGF-beta1 receptors to non-lipid raft associated pools results in augmented TGF-beta1
Smad signaling
Xiao et al., J Immunol 2008
(Autoimmune Diseases) :
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven
Smad3 signaling and
inhibiting IL-6 and IL-23 receptor expression ... Herein we show that RA enhances TGF-beta signaling by increasing the expression and phosphorylation of
Smad3 , and this results in increased Foxp3 expression even in the
presence of
IL-6 or IL-21
Lee et al., J Biol Chem 2010
:
At the intracellular level, both
Smad and p38 signaling pathways are
required for the induction of
IL-6
Ciuclan et al., Am J Respir Crit Care Med 2011
(Acute Disease...) :
Molecular analysis showed a dysregulated transforming growth factor-ß/bone morphogenetic
protein/Smad axis in SU5416- and/or hypoxia treated mice as well as augmented
induction of
IL-6 and Hif-1a levels
Ma et al., PloS one 2012
(Fibrosis) :
Macrophage stimulated cardiac fibroblast production of
IL-6 is
essential for TGF
ß/Smad activation and cardiac fibrosis induced by angiotensin II