◀ Back to CSF3
CEBPA — CSF3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Schuster et al., Blood 2003
:
In 32Dcl3 cells transfected with the bcr-abl gene ( 32D ( Bcr-Abl ) ),
G-CSF did not
trigger either granulocytic differentiation or the up-regulation of
C/EBPalpha , C/EBPepsilon, and the G-CSFR
Iida et al., Genes Cells 2008
:
Chromatin immunoprecipitation ( ChIP ) and electrophoretic mobility shift assays revealed that
G-CSF activates
C/EBPalpha to bind target promoters ... All the
G-CSF induced
C/EBPalpha recruitment, transcriptional activation and histone modifications were reversed by re-stimulation with IL-3, and were abolished by short hairpin RNA ( shRNA ) -mediated knockdown of C/EBPalpha ... These results indicate that
C/EBPalpha is
activated by
G-CSF to bind target promoters, and plays critical roles in the transcriptional activation and dynamic chromatin modification of target genes during neutrophil differentiation
Feng et al., Br J Haematol 2009
:
Finally, the
CSF3 induced transcription factor
C/EBPalpha enhanced transcription of a host gene of miR-27, C9orf3, via activation of its promoter
Jack et al., Blood 2009
(MAP Kinase Signaling System) :
In summary, M-CSF activates ERK more potently than G-CSF, and thereby
induces higher levels of c-Fos and
phospho-C/EBPalpha ( S21 ), which may directly interact to favor monopoiesis, whereas
G-CSF activates signal transducer and activator of transcription 3 and SHP2, potentially shifting the balance to granulopoiesis via gene induction by C/EBPalpha homodimers and via effects of SHP2 on regulators besides ERK