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AGO2 — HSP90AA1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: AGO2 — HSP90AA1 (physical association, affinity chromatography technology) Fabian et al., Mol Cell 2009
• IRef Biogrid Interaction: AGO2 — HSP90AA1 (physical association, affinity chromatography technology) Maniataki et al., Genes Dev 2005*
• IRef Intact Interaction: Complex of 76 proteins (association, anti tag coimmunoprecipitation) Weinmann et al., Cell 2009
• IRef Intact Interaction: Complex of 43 proteins (association, anti tag coimmunoprecipitation) Weinmann et al., Cell 2009
• IRef Intact Interaction: Complex of DICER1-HSP90AA1-AGO2-PIWIL4 (physical association, cosedimentation through density gradient) Tahbaz et al., EMBO Rep 2004*
• IRef Intact Interaction: Complex of 16 proteins (association, anti tag coimmunoprecipitation) Dächsel et al., Parkinsonism Relat Disord 2007

Text-mined interactions from Literome

Miyoshi et al., Nature structural & molecular biology 2010 : Here we show that Hsp90 is required for Ago2 to receive the small interfering RNA ( siRNA ) duplex from the RNA induced silencing complex loading complex in RNAi, suggesting a model where Hsp90 modifies Ago2 conformation to accommodate the siRNA duplex
Martinez et al., RNA 2013 : Inhibition of Hsc70/Hsp90 led to decreased Ago2 expression consistent with the reported role of this chaperone complex in RISC assembly