Gene interactions and pathways from curated databases and text-mining

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IL8 — MTX1

Text-mined interactions from Literome

Neuman et al., Clin Biochem 1999 : MTX + EtOH increased the release of IL 6, IL 8 and TNF alpha by 1.0, 1.2, and 1.1 times, respectively
Seitz et al., Rheumatol Int 1992 (Arthritis, Psoriatic...) : Gold sodium thiomalate (GST) and methotrexate (MTX) inhibited the spontaneous and stimulated IL-8 production by PBMC by 55-86 % at 50 and 10 micrograms/ml, respectively
Meyer et al., J Rheumatol 1993 (Arthritis, Rheumatoid) : MTX had no effect on interleukin 1 stimulated production of prostaglandin E, hyaluronic acid and collagenase
Okuda et al., Eur J Haematol 1997 : Furthermore, MTX caused a significant inhibition of both superoxide production induced by phorbol 12-myristate-13-acetate and chemotaxis induced by interleukin 8 in G-CSF primed neutrophils