◀ Back to IL8
IL8 — SST
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Chowers et al., J Immunol 2000
:
Somatostatin through its specific receptor
inhibits spontaneous and TNF-alpha- and bacteria induced
IL-8 and IL-1 beta secretion from intestinal epithelial cells ... Octreotide, which mainly stimulates somatostatin receptor subtypes 2 and 5, affected the secretion of
IL-8 and IL-1beta similarly, and the somatostatin antagonist
cyclo-somatostatin completely
blocked the somatostatin- and octreotide induced inhibitory effects
Andoh et al., Int J Mol Med 2002
(Acute Disease...) :
To elucidate the mechanisms mediating the therapeutic actions of somatostatin on acute pancreatitis, we investigated how
somatostatin affects the tumor necrosis factor (TNF)-alpha induced interleukin (IL)-6 and
IL-8 secretion from pancreatic myofibroblasts
Vindeløv et al., Growth Horm IGF Res 2011
(Adenoma...) :
Interleukin-8 production from human somatotroph adenoma cells is
stimulated by interleukin-1ß and inhibited by growth hormone releasing hormone and
somatostatin ... The cultured adenoma cells released both IL-6 and
IL-8 and the secretion was
inhibited by GHRH and
somatostatin
Peluso et al., Neuropeptides 1996
:
Although
somatostatin affected
IL-8 production in an indirect way, it suppressed directly the chemotactic response of neutrophils to IL-8
Beales et al., Gastroenterology 1997
:
Effect of transforming growth factor alpha and
interleukin 8 on
somatostatin release from canine fundic D cells ... The aim of this study was to examine whether
IL-8 and TNF-alpha could
regulate somatostatin release from isolated canine gastric D cells
Hernanz et al., J Neuroimmunol 1996
:
Differential
effects of gastrin releasing peptide, neuropeptide Y,
somatostatin and vasoactive intestinal peptide on interleukin-1 beta,
interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects