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GDI1 — RAC2
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
RAC2
→
GDI1
(reaction)
Scheffzek et al., Nat Struct Biol 2000, Hoffman et al., Cell 2000, Robbe et al., J Biol Chem 2003, Hart et al., Science 1992, Sun et al., J Biol Chem 2004, DerMardirossian et al., Trends Cell Biol 2005, Bächner et al., Hum Mol Genet 1995, Adra et al., Proc Natl Acad Sci U S A 1997, Gosser et al., Nature 1997
-
Reactome Reaction:
RAC2
→
GDI1
(indirect_complex)
Scheffzek et al., Nat Struct Biol 2000, Hoffman et al., Cell 2000, Hart et al., Science 1992, Sun et al., J Biol Chem 2004, DerMardirossian et al., Trends Cell Biol 2005, Bächner et al., Hum Mol Genet 1995, Adra et al., Proc Natl Acad Sci U S A 1997, Gosser et al., Nature 1997
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Di-Poï et al., Biochemistry 2001
:
These data suggest that
Rho-GDI stabilizes
Rac in an active conformation, even in the GDP bound state, and presents it to its effector, the p67phox component of the NADPH oxidase
Groysman et al., J Biol Chem 2002
:
Surprisingly, Vav1 associates with
Ly-GDI , a hematopoietic cell-specific guanine nucleotide dissociation
inhibitor of
Rac