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IL8 — TREM1
Text-mined interactions from Literome
Bouchon et al., J Immunol 2000
(Calcium Signaling...) :
Engagement of
TREM-1 triggers secretion of
IL-8 , monocyte chemotactic protein-1, and TNF-alpha and induces neutrophil degranulation
Fortin et al., Int Immunol 2007
:
The engagement of
TREM-1 on PMN can
induce phagocytosis, reactive oxygen species production and release of myeloperoxidase and
IL-8
Murakami et al., J Immunol 2007
:
Activation of
TREM-1 expressed on PGE ( 2 ) -pretreated PBMC by an agonistic TREM-1 mAb significantly
enhanced the production of
IL-8 and TNF-alpha
Schmausser et al., Clin Exp Immunol 2008
(Gastritis...) :
Stimulation of gastric epithelial
TREM-1 receptor
resulted in
IL-8 up-regulation on mRNA and protein level, as shown by real-time PCR and immunoassay
Amatngalim et al., Inflammation 2011
(Inflammation) :
LL-37 did not affect
TREM-1 induced neutrophil degranulation or the production of reactive oxygen species and
interleukin-8 by neutrophils
McMahon et al., Infect Immun 2011
:
Activation of
TREM-1 on the GEC
led to an increase in
interleukin-8 (IL-8) mRNA levels
Li et al., Dev Comp Immunol 2011
:
Functionally, canine
TREM-1 synergistically
enhances LPS induced production of
IL-8 , TNF-a and a canine orthologue of CXCL1
Ormsby et al., Blood 2011
(Agammaglobulinemia...) :
Importantly,
TREM-1 induced production of the pro-inflammatory cytokines, TNF-a and
IL-8 , and up-regulation of activation/differentiation cell surface markers were impaired in Btk knockdown cells
Wang et al., Bosn J Basic Med Sci 2012
:
Our finding that
TREM-1 controls the production of
IL-8 and TNF-a in U937 foam cells defines a potentially critical role of TREM-1 in the pathogenesis of atherosclerosis and implicates TREM-1 as a potential therapeutic target for the disease