Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
CCR2
→
CRP
(increases, CRP Translocation)
Han et al., Circulation 2004* Evidence: Serum high-sensitivity CRP levels in 52 normocholesterolemic human subjects were positively correlated with CCR2 surface expression on circulating monocytes (r=0.62, P<0.001) and MCP-1-mediated monocyte chemotaxis (r=0.53, P<0.001). CONCLUSIONS: Elevated blood CRP levels may promote accumulation of monocytes in the atherogenic arterial wall by increasing chemotactic activities of monocytes in response to MCP-1.