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MAP3K1 — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kim et al., J Biol Chem 2000
:
Taken together with previous observations, these results implicate that, for the assembly of an IFN-beta enhanceosome,
MEKK1 can
induce IRF3 and ATF2/c-JUN through the JNK pathway, whereas it can induce
NF-kappaB through the IKK pathway
Baumann et al., Proc Natl Acad Sci U S A 2000
:
Raf rather synergizes with another membrane shuttle kinase MEKK1, and Raf mediated activation of
NF-kappaB is
blocked by a dominant negative form of
MEKK1
Yujiri et al., Proc Natl Acad Sci U S A 2000
:
MEKK1 is
required for JNK but not
NF-kappaB activation in response to virus infection, microtubule disruption, and stimulation of embryonic stem cells with lysophosphatidic acid ... Thus,
MEKK1 senses microtubule integrity, contributes to the regulation of fibroblast and epithelial cell migration, and is
required for activation of JNK but not
NF-kappaB in response to selected stress stimuli
Wang et al., J Biol Chem 2001
(Cell Transformation, Neoplastic) :
Expression of dominant negative M-Ras ( S27N ), dominant negative
MEKK1 ( K432M ), or specific chemical inhibitors for p38 MAP kinase ( SB202190 and SB203580 )
block MGSA/GROalpha induced
NF-kappaB transactivation, demonstrating that Ras, MEKK1, and p38 are involved in the signal pathways of MGSA/GROalpha activation of NF-kappaB ... Expression of dominant active Ras or dominant active
MEKK1 alone can also
stimulate NF-kappaB activation ... The expression of dominant negative
MEKK1 inhibits the Ras induced
NF-kappaB activation, suggesting that MEKK1 is a downstream target of Ras
Das et al., J Biol Chem 2001
:
In contrast, wild-type
MEKK1 or JNK kinase
induced NF-kappaB activation alone or in combination with thioredoxin expression plasmid
Ludwig et al., Cancer Res 2001
(Carcinoma, Medullary...) :
In contrast, RET induced
NF-kappaB activity is
dependent on Raf and
MEKK1
Chiao et al., Cancer 2002
(Carcinoma, Hepatocellular...) :
The current study data demonstrate that 1 ) RelA/NF-kappaB activity is activated constitutively in Hep3B cells, as determined by electrophoretic mobility shift assays ; 2 )
RelA/NF-kappaB reporter gene activity is
inhibited specifically by dominant negative mutants of IkappaB(alpha), IKK1, IKK2,
MEKK1 , and MEKK3 and it is activated by overexpression of wild-type MEKK3, suggesting that upstream kinase cascades induce phosphorylation of IkappaB(alpha) and activate RelA/NF-kappaB in Hep3B cells ; 3 ) overexpression of the HBV x gene fails to activate NF-kappaB in HepG2 and Chang cell lines ; 4 ) The NF-kappaB-inducible gene, bcl-xl, is overexpressed in Hep3B cells and is inhibited by the proteosome inhibitor PS341, which prevents IkappaBalpha degradation and RelA/NF-kappaB activation ; and 5 ) inhibition of constitutive RelA/NF-kappaB activity by PS341 sensitizes Hep3B cells to doxorubicin induced apoptosis
O'Reilly et al., Biochem Biophys Res Commun 2003
:
Furthermore full length and C-terminal A20 showed similar regulatory effects on
MEKK-1 activation of
NF-kappa B and AP-1 and induction of IL-8
Nawata et al., Oncogene 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Expression of
MEKK1km also
reduced NF-kappaB activation, and inhibited antiapoptotic c-IAP1 and c-IAP2 mRNA expression in response to the genotoxin
Lan et al., J Helminthol 2004
(Brain Diseases...) :
These data suggest that the development of brain injury by eosinophilia of A. cantonensis infection is associated with activation of JAK/STAT1 signals by cytokines, and/or activation of
MEKK1/JNK by oxidant stress, and/or
activation of
NF-kappaB by increasing IAP expression
Neumann et al., Biol Chem 2006
:
Furthermore, we show that mitogen activated protein kinase kinase kinases (
MAP3K ), like TPL2 ( tumour progression locus 2 ) and transforming growth factor beta activated kinase 1 ( TAK1 ), have no impact on H. pylori
induced activation of
NF-kappaB
Gohda et al., Biochem Biophys Res Commun 2007
:
These results strongly suggest that unlike cytokine signaling, Tax induced
NFkappaB activation does not
involve K63 polyubiquitination mediated
MAP3K activation
Mokhtari et al., Diabetes 2008
:
MEKK-1 mediates cytokine induced JNK- and
NF-kappaB activation, and this event is necessary for iNOS expression and cell death
Mendoza et al., Apoptosis 2008
:
MEK kinase 1 (MEKK1) is a serine threonine kinase that is activated following etoposide treatment and
activates NF-kappaB
Yoshida et al., J Biol Chem 2008
(MAP Kinase Signaling System) :
These data suggest that IPS-1
requires TRAF6 and
MEKK1 to activate
NF-kappaB and mitogen activated protein kinases that are critical for the optimal induction of type I interferons
Grotterød et al., BMC cancer 2010
(Osteosarcoma) :
Dominant negative
MEKK1 or NIK did not
inhibit S100A4 induced
NF-kappaB activity, and S100A4 stimulation did not influence AKT phosphorylation
Nakano et al., Proc Natl Acad Sci U S A 1998
:
Moreover, a catalytically inactive mutant of IKKbeta blocked the
MEKK1 induced
NF-kappaB activation
Lee et al., Proc Natl Acad Sci U S A 1998
:
We conclude that IKK-alpha and IKK-beta can mediate the
NF-kappaB inducing activity of
MEKK1
Wang et al., Clin Cancer Res 1999
(Adenocarcinoma...) :
I kappa B alpha, a previously identified NF-kappa B-inducible gene, was overexpressed in human pancreatic tumor tissues and cell lines, and
RelA activation could be
inhibited by curcumin and dominant negative mutants of I kappa B alpha, raf, and
MEKK1