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NOS1 — PTGS2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
NOS1
—
PTGS2
(interaction, mapped from dip)
-
STRING interaction:
PTGS2
—
NOS1
(interaction, mapped from dip)
Text-mined interactions from Literome
Cheng et al., American journal of physiology. Renal physiology 2000
:
The cultured cells expressed immunoreactive
nNOS , and 7-NI
inhibited basal
COX-2 immunoreactivity expression, which could be partially overcome by cGMP
Lomnitski et al., Pharmacol Toxicol 2000
(Liver Diseases) :
Effects of apocynin and natural antioxidant from spinach on inducible
nitric oxide synthase and
cyclooxygenase-2 induction in lipopolysaccharide induced hepatic injury in rat
Chang et al., Mol Cell Biol 2000
:
This increased
nNOS activity as well as increased nNOS dimer after NGF withdrawal were
inhibited by
COX-2 or DLC/PIN overexpression
Chen et al., Br J Pharmacol 2003
:
Signal transduction for inhibition of inducible
nitric oxide synthase and
cyclooxygenase-2 induction by capsaicin and related analogs in macrophages
Park et al., Int J Cancer 2003
(Carcinoma, Squamous Cell...) :
This increase of
COX-2 expression by SNAP or PMA ( potent inducer of both iNOS and COX-2 ) was
blocked to various degrees by NO scavengers and
NOS inhibitors ( L-NAME and 1400W ) ... Also, the expression of
COX-2 in resting cells was
inhibited by
NOS inhibitors
Ishimura et al., Am J Physiol Gastrointest Liver Physiol 2004
:
Inducible
nitric oxide synthase upregulates
cyclooxygenase-2 in mouse cholangiocytes promoting cell growth
Rigas et al., Trends Mol Med 2004
(Neoplasms) :
Mechanistically, NO-aspirin, the best studied NO-NSAID, has pleiotropic effects on cell signaling ( it inhibits Wnt signaling, induces
nitric oxide synthase and NF-kappaB activation and
induces cyclooxygenase-2 expression ), and this mechanistic redundancy might be central to its mode of action against cancer
Ejima et al., Antioxid Redox Signal 2004
(Endotoxemia) :
The present article reviews our recent studies involving the role of cyclooxygenase
(COX)-2 in host responses to bacterial endotoxemia and its
role in the regulation of
nitric oxide synthase (NOS)2 and heme oxygenase (HO)-1
Clark et al., Biochem J 2005
(Inflammation) :
PGHS-2 ( prostaglandin H synthase-2 ) is
induced in mammalian cells by pro-inflammatory cytokines in tandem with iNOS [ high-output ( ` inducible ' )
nitric oxide synthase ], and is co-localized with iNOS and nitrotyrosine in human atheroma macrophages
Rodriguez et al., Am J Physiol Heart Circ Physiol 2006
:
In addition, we conclude that the activation of mitogen activated protein kinases p42/p44, protein kinase C, and
nitric oxide synthase is
necessary for the increase in
COX-2 levels induced by BK because either of the specific inhibitors for these enzymes blocked the effect of BK. Using a similar approach, we further demonstrated that reactive oxygen species and cAMP were not mediators on this pathway
Datta et al., Nephrol Dial Transplant 2006
(Disease Models, Animal...) :
Regulatory
effects of inducible
nitric oxide synthase on
cyclooxygenase-2 and heme oxygenase-1 expression in experimental glomerulonephritis
Chen et al., Eur J Pharmacol 2006
:
We show that dipyridamole inhibited interleukin-6 and monocyte chemoattractant protein-1 secretion, inducible
nitric oxide synthase protein expression, nitrite accumulation, and
cyclooxygenase-2 (COX-2) induction in lipopolysaccharide (LPS) activated RAW 264.7 macrophages
Ramana et al., Circulation 2006
(Cardiomyopathies...) :
These changes were associated with decreased myocardial nuclear factor-kappaB and activating protein-1 activity, prostaglandin E2 production,
induction of
cyclooxygenase 2 , and inducible
nitric oxide synthase
Varga et al., Headache 2007
:
Cox-2 inhibitor
attenuates NO-induced
nNOS in rat caudal trigeminal nucleus
Reese et al., Prostaglandins Other Lipid Mediat 2009
:
However,
NOS inhibition followed by selective
COX-2 inhibition caused unexpected ductal dilation
Liao et al., Toxicol Lett 2009
:
In studying the mechanisms involved in alpha-Triol induced COX-2/PGE ( 2 ) production, inhibitors of
NOS , PI3K, p38, and NF-kappaB, effectively
attenuated COX-2 protein induction and mRNA expression, suggesting that the PI(3)K-Akt-eNOS pathway, p38MAPK, and NF-kappaB are involved in alpha-Triol induced COX-2 expression, and following increases in p38 and Akt phosphorylation, the concentration dependent inhibition of COX-2 protein expression by L-NAME further suggested their involvement at the translation level
Ohtsu et al., Oncol Rep 2010
(Carcinoma, Squamous Cell) :
Antitumor
effects of inhibitors of
nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing
COX-2
Resta-Lenert et al., Am J Physiol Gastrointest Liver Physiol 2011
:
Reduction of endogenous MUC17 is associated with increased permeability, inducible
nitric oxide synthase and
cyclooxygenase 2 induction , and enhanced bacterial invasion in response to EIEC exposure
Prati et al., Arthritis Res Ther 2012
(Arthritis, Experimental...) :
The results showed that this beneficial effect is mediated by an increase in
NOS activity and EDHF and
reduced superoxide anion production as well as a decrease in the activity of cyclooxygenase
(COX)-2 , thromboxane and prostacyclins synthases
Wu et al., Journal of neuroinflammation 2012
(Disease Models, Animal...) :
Neuroinflammation in RVLM was also associated with a
COX-2 dependent downregulation of endothelial
nitric oxide synthase and an upregulation of intercellular adhesion molecule-1
Obermajer et al., Transplantation research 2012
:
We observed that PGE2 induces endogenous cyclooxygenase
(COX)2 expression in cultured monocytes, blocking their differentiation into CD1a+ dendritic cells (DCs) and
inducing the expression of indoleamine 2,3-dioxygenase 1, IL-4Ra,
nitric oxide synthase 2 and IL-10 - typical MDSC associated suppressive factors
Beltrame et al., Placenta 2013
:
Also,
cyclooxygenase-2 derived prostaglandins
mediated LPA-stimulatory action on
NOS activity
Pang et al., Eur J Pharmacol 1996
:
Induction of cyclooxygenase and
nitric oxide synthase in endotoxin activated J774 macrophages is differentially
regulated by indomethacin : enhanced
cyclooxygenase-2 protein expression but reduction of inducible nitric oxide synthase