UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database IL12-mediated signaling events: STAT4 (STAT4) → IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2) (modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: reporter gene
NCI Pathway Database IL12-mediated signaling events: IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2) → STAT4 (dimer) complex (STAT4) (modification, activates)
Yoshimoto et al., J Immunol 2003
Evidence: reporter gene
NCI Pathway Database IL12-mediated signaling events: SPHK2 (SPHK2) → IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) (modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
NCI Pathway Database IL12-mediated signaling events: SPHK2 (SPHK2) → IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2) (modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
NCI Pathway Database IL12-mediated signaling events: IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) → IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2) (modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species